An Evaluation of the Association of Reproductive History and Multiple Births during Adolescence with Postmenopausal Osteoporosis

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dc.contributor.authorKaya, Aşkı Ellibeş
dc.contributor.authorDoğan, Ozan
dc.contributor.authorBaşbuğ, Alper
dc.contributor.authorSönmez, Cemil Işık
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorAtaoğlu, Safinaz
dc.date.accessioned2020-04-30T22:39:11Z
dc.date.available2020-04-30T22:39:11Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptiondogan, ozan/0000-0002-0016-8749en_US
dc.descriptionWOS: 000461592500013en_US
dc.descriptionPubMed: 30880829en_US
dc.description.abstractIntroduction Osteoporosis is the most common metabolic bone disease characterized by low bone mass. Reproductive factors are known to affect bone mineral density (BMD). Calcium loss from maternal bone and decreased BMD have been observed especially during pregnancy and lactation, although this loss has been reported to recover within 6-12 months. There is no consensus on whether the effect of reproductive factors on the bone is positive or negative. The adolescent period is important for total bone mass, and total bone mass is significant in osteoporosis. The aim of this study was to investigate the effect of first gestational age, multiple births during adolescence, interpregnancy interval and reproductive history such as duration of breastfeeding on bone mineral density in postmenopausal women. Materials and Methods BMD was measured in a total of 196 postmenopausal patients and in accordance with the results, analysis was made of three groups as normal, osteopenia and osteoporosis. Dual Energy X-Ray Absorptiometry (DEXA) was used to take the lumbar, femoral and total bone BMD measurements. Results No statistically significant difference was determined between the groups in respect of total breastfeeding time (p = 0.596). It was detected that an increased interpregnancy interval decreased the risk of osteoporosis. In patients with osteoporosis, the mean interpregnancy interval was 1.4 +/- 0.73 years, while it was longer in patients with osteopenia (1.92 +/- 1.20) and normal BMD (2.45 +/- 1.77) (p = 0.005). While no effect was determined of the first gestational age on BMD, in the univariate logistic regression analysis, multiple births in the adolescent period were seen to increase the risk of osteoporosis 6.833-fold (p = 0.001, OR = 6.833, 95% CI = 2.131-21.908; p = 0.001). The increase in the age of menopause was determined to decrease the risk of osteoporosis (OR = 0.911, 95% CI = 0.843-0.985; p = 0.019). Conclusion Having frequent births throughout the whole reproductive age and having more than one child in adolescence has an adverse effect on postmenopausal bone mineral densities.en_US
dc.identifier.doi10.1055/a-0743-7260en_US
dc.identifier.endpage307en_US
dc.identifier.issn0016-5751
dc.identifier.issn1438-8804
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage300en_US
dc.identifier.urihttps://doi.org/10.1055/a-0743-7260
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2631
dc.identifier.volume79en_US
dc.identifier.wosWOS:000461592500013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofGeburtshilfe Und Frauenheilkundeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectadolescenten_US
dc.subjectbreastfeedingen_US
dc.subjectbone mineral densityen_US
dc.subjectpostmenopausal osteoporosisen_US
dc.subjectinterpregnancy intervalen_US
dc.titleAn Evaluation of the Association of Reproductive History and Multiple Births during Adolescence with Postmenopausal Osteoporosisen_US
dc.typeArticleen_US

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