Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study

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dc.contributor.authorDemirin, Hilmi
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorUçgun, Taner
dc.contributor.authorCeler, Ahmet
dc.contributor.authorBulur, Şule
dc.contributor.authorÇil, Habib
dc.contributor.authorYıldırım, Hayriye Ak
dc.date.accessioned2020-04-30T23:19:42Z
dc.date.available2020-04-30T23:19:42Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000295212200020en_US
dc.descriptionPubMed: 21620440en_US
dc.description.abstractAim: Mean platelet volume (MPV) in the healthy population has not been studied before. Therefore, the aim of the study was to measure MPV in normal subjects in a large cohort of Turkish adults. Methods: A total of 2298 subjects with a mean age of 50 (age range 18 to 92) were interviewed. Subjects who had smoking habit, diabetes, hypertension, coronary artery disease, dyslipidemia, chronic obstructive pulmonary disease, cancer, chronic use of any drugs including antiplatelets, heavy drinkers, metabolic syndrome, ejection fraction < 55%, creatinine > 1.4 in men and > 1.1 in women, abnormal liver function tests and an abnormal TSH were excluded in a in a stepwise manner. Complete blood counts were done on the same day within 6 hours by a CELL-DYN 3700 SL analyzer (Abbott Diagnostics). Results: Three hundred twenty-six participants (204 females (63%) and 122 males (37%) with a mean age of 41 +/- 16) constituted the final healthy cohort. Mean MPV of the cohort was 8.9 +/- 1.4 fL. There was no significant difference among age groups regarding MPV. Conclusion: Ninety-five percent of the individuals had a MPV between 7.2 and 11.7 fL. A patient having a MPV beyond this range should be evaluated carefully especially for occlusive arterial diseases. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipDuzce University Office of Scientific InvestigationsDuzce Universityen_US
dc.description.sponsorshipThis work was supported by the Duzce University Office of Scientific Investigations.en_US
dc.identifier.doi10.1016/j.thromres.2011.05.007en_US
dc.identifier.endpage360en_US
dc.identifier.issn0049-3848
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage358en_US
dc.identifier.urihttps://doi.org/10.1016/j.thromres.2011.05.007
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3830
dc.identifier.volume128en_US
dc.identifier.wosWOS:000295212200020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofThrombosis Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMean platelet volumeen_US
dc.subjectReference rangeen_US
dc.titleNormal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic studyen_US
dc.typeArticleen_US

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