The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats

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dc.contributor.authorDokucu, Ali İhsan
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorTuncer, Mehmet Cudi
dc.contributor.authorYılmaz, Fahri
dc.date.accessioned2020-04-30T23:33:27Z
dc.date.available2020-04-30T23:33:27Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionH, Ozturk/0000-0001-5608-5742; Tuncer, Mehmet Cudi/0000-0001-7317-5467;en_US
dc.descriptionWOS: 000263508000016en_US
dc.descriptionPubMed: 18787973en_US
dc.description.abstractThis study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1 alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury. Torsions were created by rotating ipsilateral testes 720A degrees in a clockwise direction for 6 h and 1-h detorsion of the testis was performed. A sham operation was performed in group 1 (control, n = 7). In group 2 (I-R/Untreated, n = 7), following 6 h of unilateral testicular torsion, 1-h detorsion of the testis was performed. No drug was given. In group 3 (I-R/MO), after performing the same surgical procedure as in group 2, a NO donor MO was given at the starting time of reperfusion. In group 4 (I-R/L-NAME), after performing the same surgical procedure as in group 2, L-NAME was given at the starting time of reperfusion. Testes malondialdehyde (MDA) levels were determined as well as examining the testes histologically. Treatment of rats with MO produced a significant reduction in the levels of MDA and histopathological score compared to testes I-R groups. The Sonic hedgehog (Shh) expression in the basement membrane of the tubuli seminiferi, and sertoli and germinal cells in testicular tissue, were greatly increased in the I-R/MO group compared to groups 1, 2 and 4. Additionally, the HIF-1 alpha expression in the interstitial spaces in testicular tissue were greatly increased in the I-R/MO group. The results suggest that MO has a protective effect against ischemia/reperfusion injury in rat testes and may affect Shh and HIF-1 alpha signaling pathway.en_US
dc.identifier.doi10.1007/s11255-008-9460-6en_US
dc.identifier.endpage108en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-008-9460-6
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4975
dc.identifier.volume41en_US
dc.identifier.wosWOS:000263508000016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology And Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia/Reperfusion injuryen_US
dc.subjectHypoxia inducible factor alpha (HIF-1 alpha)en_US
dc.subjectSonic hedgehog (Shh)en_US
dc.subjectTestesen_US
dc.titleThe effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in ratsen_US
dc.typeArticleen_US

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