Mean Platelet Volume in Patients With Major Depression Effect of Escitalopram Treatment

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dc.contributor.authorAtaoğlu, Ahmet
dc.contributor.authorCanan, Fatih
dc.date.accessioned2020-04-30T23:19:07Z
dc.date.available2020-04-30T23:19:07Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000267995200009en_US
dc.descriptionPubMed: 19593177en_US
dc.description.abstractBackground: The relationship between major depression and increased platelet activity has been previously indicated by several studies. The aims of this study were to examine mean platelet volume (MPV), which is an indicator of platelet activity, in patients with depression and investigate whether escitalopram treatment would affect MPV. Methods: Fifteen patients (11 women and 4 men) meeting the criteria for a current episode of major depressive disorder were recruited to the study and 17 physically and mentally healthy comparison subjects (11 women and 6 men). Mean platelet volume and platelet count of the controls and patients were measured upon entry to the study. After 8 weeks of open-label treatment with the selective serotonin reuptake inhibitor escitalopram (10-20 mg/d), the patients with depression were readmitted and the measurements were repeated. Results: At baseline, in comparison with the control group, the group with depression exhibited greater platelet activity as detected by increased MPV After escitalopram treatment, the patients with depression exhibited significant reduction in MPV There was also a significant decline in platelet count. Conclusions: In this study, normalization of platelet activation is associated with escitalopram treatment for patients with depression. This finding may provide evidence for the use of escitalopram in patients with major depression and comorbid ischemic heart disease.en_US
dc.identifier.doi10.1097/JCP.0b013e3181abdfd7en_US
dc.identifier.endpage371en_US
dc.identifier.issn0271-0749
dc.identifier.issn1533-712X
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage368en_US
dc.identifier.urihttps://doi.org/10.1097/JCP.0b013e3181abdfd7
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3654
dc.identifier.volume29en_US
dc.identifier.wosWOS:000267995200009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectescitalopramen_US
dc.subjectmajor depressive disorderen_US
dc.subjectmean platelet volumeen_US
dc.subjectplatelet activityen_US
dc.titleMean Platelet Volume in Patients With Major Depression Effect of Escitalopram Treatmenten_US
dc.typeArticleen_US

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