Mean Platelet Volume in Patients With Major Depression Effect of Escitalopram Treatment
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Dosyalar
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The relationship between major depression and increased platelet activity has been previously indicated by several studies. The aims of this study were to examine mean platelet volume (MPV), which is an indicator of platelet activity, in patients with depression and investigate whether escitalopram treatment would affect MPV. Methods: Fifteen patients (11 women and 4 men) meeting the criteria for a current episode of major depressive disorder were recruited to the study and 17 physically and mentally healthy comparison subjects (11 women and 6 men). Mean platelet volume and platelet count of the controls and patients were measured upon entry to the study. After 8 weeks of open-label treatment with the selective serotonin reuptake inhibitor escitalopram (10-20 mg/d), the patients with depression were readmitted and the measurements were repeated. Results: At baseline, in comparison with the control group, the group with depression exhibited greater platelet activity as detected by increased MPV After escitalopram treatment, the patients with depression exhibited significant reduction in MPV There was also a significant decline in platelet count. Conclusions: In this study, normalization of platelet activation is associated with escitalopram treatment for patients with depression. This finding may provide evidence for the use of escitalopram in patients with major depression and comorbid ischemic heart disease.
Açıklama
WOS: 000267995200009
PubMed: 19593177
PubMed: 19593177
Anahtar Kelimeler
escitalopram, major depressive disorder, mean platelet volume, platelet activity
Kaynak
Journal Of Clinical Psychopharmacology
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
29
Sayı
4
