Correlation of astrocyte elevated gene-1, basic-fibroblast growth factor, beta-catenin, Ki-67, tumor necrosis factor-alfa with prognostic parameters in ductal carcinomas and ductal intraepithelial neoplasms

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dc.contributor.authorErdem, Havva
dc.contributor.authorGündoğdu, Betül
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorYaşar, Mehmet
dc.contributor.authorŞener, Ebru
dc.contributor.authorOktay, Murat
dc.contributor.authorŞahiner, Cem
dc.date.accessioned2020-04-30T22:41:48Z
dc.date.available2020-04-30T22:41:48Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Handan Camdeviren/0000-0002-3613-0523;en_US
dc.descriptionWOS: 000356942700012en_US
dc.descriptionPubMed: 26096243en_US
dc.description.abstractBackground: Breast cancer is the second most frequent cancer in the world. Although it is widely accepted that the etiology of breast cancer includes both genetic and environmental factors, the molecular mechanism of its development and progression remains poorly understood, and thus far, no specific signature of breast cancer gene expression has been reported to allow for patient-tailored therapy strategies. Hence, it is of great clinical value to further understand the molecular mechanisms underlying the progression of breast cancer and to identify effective early markers for the diagnosis and prognosis of the disease as well as novel therapeutic targets. Materials and Methods: This study was conducted on a total of 90 paraffin-embedded breast tumor samples. Immunohistochemical stains for astrocyte elevated gene-1 (AEG-1), basic-fibroblast growth factor (b-FGF), beta-catenin, Ki-67, tumor necrosis factor- (TNF-) were performed on tissue microarray using standard procedures. Each patient age, grade, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) status, size, lymphovascular invasion, metastasis of lymph node (LNM), nipple and ductal hyperplasia areas were assessed. Results: We observed significant relationship between the age and LNM or FGF (P = 0.018, 0.035, respectively). The relationship between histological and nuclear grade, LNM, ER, PR, HER-2 and prognostic parameters was evaluated in cases of ductal carcinomas (DC). There was a significant positive correlation between TNF-, size, LNM (P % 0.0001, 0.002, 0.005). We found that significant relationship between AEG-1 and TNF-. There was a significant positive correlation between FGF and Ki-67 and negative correlation AEG-1. Although, FGF, TNF-, AEG-1 staining in DC were observed higher than ductal intraepithelial neoplasms, this observation could not statistically (P >= 0.05). Conclusions: The present work aims to investigate the relationship between the expression of AEG-1, b-FGF, beta-catenin, Ki-67, TNF- other prognostic parameters in DC and ductal intraepithelial neoplasm. We found a relationship between these factors.en_US
dc.description.sponsorshipDuzce University ResearchDuzce Universityen_US
dc.description.sponsorshipThis project is supported by Duzce University Research. We thank Dr. Hilal Balta for help this study.en_US
dc.identifier.doi10.4103/1119-3077.158961en_US
dc.identifier.endpage643en_US
dc.identifier.issn1119-3077
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage638en_US
dc.identifier.urihttps://doi.org/10.4103/1119-3077.158961
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3251
dc.identifier.volume18en_US
dc.identifier.wosWOS:000356942700012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofNigerian Journal Of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAstrocyte elevated gene-1en_US
dc.subjectbeta-cateninen_US
dc.subjectbasic-fibroblast growth factoren_US
dc.subjectductal carcinomasen_US
dc.subjectprognostic parametersen_US
dc.subjecttumor necrosis factor-en_US
dc.titleCorrelation of astrocyte elevated gene-1, basic-fibroblast growth factor, beta-catenin, Ki-67, tumor necrosis factor-alfa with prognostic parameters in ductal carcinomas and ductal intraepithelial neoplasmsen_US
dc.typeArticleen_US

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