Does pregnancy-associated plasma protein A have a role in allergic rhinitis?

Basit Öğe Kaydı
dc.contributor.authorGüçlü, Ender
dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorTokmak, Abdurrahman
dc.contributor.authorDuran, Sadık
dc.contributor.authorÖztürk, Özcan
dc.contributor.authorAkkan, Nermin
dc.contributor.authorEgeli, Erol
dc.date.accessioned2020-05-01T09:11:29Z
dc.date.available2020-05-01T09:11:29Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionCoskun, Abdurrahman/0000-0002-1273-0604en_US
dc.descriptionWOS: 000256132300001en_US
dc.descriptionPubMed: 18588751en_US
dc.description.abstractBackground: Pregnancy-associated plasma protein A (PAPP-A), also known as insulin-like growth factor binding protein 4 protease, is postulated to be a new inflammatory marker in various clinical situations such as cardiovascular events, dialysis, renal transplantation, and asthma. PAPP-A also is produced in high concentrations by trophoblasts during pregnancy. Methods: We evaluated PAPP-A levels in allergic rhinitis patients and compared these with levels in healthy subjects. Thirty-one newly diagnosed allergic rhinitis patients and 29 healthy controls were included in the study. Serum PAPP-A, IgE, urea, creatinine, aspartate aminotransferase, creatine kinase (CK), CK-MB isoenzyme, total cholesterol, and triglyceride levels were determined. Results: The serum PAPP-A level was significantly higher (p = 0.013) in the allergic rhinitis group (6.1 +/- 2.9 mU/L) than in the control group (4.5 +/- 1.7 mU/L). The PAPP-A level in patients with allergic rhinitis and asthma (6.1 +/- 2.3 mU/L) was not significantly different (p = 0.959) from that in patients with allergic rhinitis alone (6.1 +/- 3.3 mU/L). The serum PAPP-A level in allergic rhinitis patients who had turbinate hypertrophy (6.9 +/- 2.2 mU/L) had a tendency to be higher than that in patients who had no turbinate hypertrophy (5.5 +/- 3.2 mU/L); however, this difference was not statistically significant (p = 0.151). Conclusion: Increased PAPP-A activity may be involved in the inflammation and tissue remodelling that occurs in allergic rhinitis.en_US
dc.identifier.doi10.2500/ajr.2008.22.3179en_US
dc.identifier.endpage222en_US
dc.identifier.issn1050-6586
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.2500/ajr.2008.22.3179
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5621
dc.identifier.volume22en_US
dc.identifier.wosWOS:000256132300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOcean Side Publications Incen_US
dc.relation.ispartofAmerican Journal Of Rhinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectallergic rhinitisen_US
dc.subjecthypervascularityen_US
dc.subjectIGFen_US
dc.subjectIGFBP-4en_US
dc.subjectinflammationen_US
dc.subjectmatrix metalloproteinaseen_US
dc.subjectnasal mucosaen_US
dc.subjectPAPP-Aen_US
dc.subjectpregnancyen_US
dc.subjecttissue remodelingen_US
dc.titleDoes pregnancy-associated plasma protein A have a role in allergic rhinitis?en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
5621.pdf
Boyut:
85.73 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu