Assessment of the genotoxicity of propineb in mice bone marrow cells using micronucleus assay

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dc.contributor.authorRasgele, Pınar Göç
dc.contributor.authorMuranlı, Fulya Dilek Gökalp
dc.contributor.authorKekeçoğlu, Meral
dc.date.accessioned2020-04-30T22:39:49Z
dc.date.available2020-04-30T22:39:49Z
dc.date.issued2014
dc.departmentDÜ, Ziraat Fakültesi, Biyosistem Mühendisliği Bölümüen_US
dc.descriptionWOS: 000340561000005en_US
dc.description.abstractPropineb, a dithiocarbamate fungicide, is commonly used for the control of disease in a wide range of crops in agriculture. The genotoxic effects of commercial formulation of propineb in bone marrow cells of mice was investigated in vivo by micronucleus (MN) assay. The three different concentrations of propineb (12.5, 25 and 50 mu g/mL; 0.01 mL per gram) were injected intraperitoneally (i.p.) to mice for 24 and 48 h. The results of the MN assay indicated that propineb induced a significant increase in frequency of micronucleated polychromatic erythrocytes (MNPCE) at 25 and 50 mu g/mL concentrations for 24 h and at the highest (50 mu g/mL) concentration for 48 h when compared with negative control. Also significant reduction for the polychromatic erythrocyte/normochromatic erythrocyte (PCE/NCE) ratio which is indicative for bone marrow cytotoxicity was observed at the same concentrations for 24 and 48 h. These results lead us to the conclusion that propineb may have genotoxic and cytotoxic potential due to induction in the frequency of MN and a reduction in PCE/NCE ratio in the bone marrow cells of mice.en_US
dc.description.sponsorshipDuzce University Scientific Research FundDuzce University [2011.05.01.070]en_US
dc.description.sponsorshipThis study was a part of scientific research titled "Micronucleus induction in mice bone marrow and human lymphocytes after exposure to mixture of pesticides acetamiprid-propineb" and it was supported by Duzce University Scientific Research Fund (project no. 2011.05.01.070).en_US
dc.identifier.doi10.3103/S0095452714040045en_US
dc.identifier.endpage237en_US
dc.identifier.issn0095-4527
dc.identifier.issn1934-9440
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage233en_US
dc.identifier.urihttps://doi.org/10.3103/S0095452714040045
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2835
dc.identifier.volume48en_US
dc.identifier.wosWOS:000340561000005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAllerton Press Incen_US
dc.relation.ispartofCytology And Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdithiocarbamateen_US
dc.subjectfungicideen_US
dc.subjectmice bone marrow cellsen_US
dc.subjectmicronucleus assayen_US
dc.subjectpropineben_US
dc.titleAssessment of the genotoxicity of propineb in mice bone marrow cells using micronucleus assayen_US
dc.typeArticleen_US

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