Assessment of the genotoxicity of propineb in mice bone marrow cells using micronucleus assay
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Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Allerton Press Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Propineb, a dithiocarbamate fungicide, is commonly used for the control of disease in a wide range of crops in agriculture. The genotoxic effects of commercial formulation of propineb in bone marrow cells of mice was investigated in vivo by micronucleus (MN) assay. The three different concentrations of propineb (12.5, 25 and 50 mu g/mL; 0.01 mL per gram) were injected intraperitoneally (i.p.) to mice for 24 and 48 h. The results of the MN assay indicated that propineb induced a significant increase in frequency of micronucleated polychromatic erythrocytes (MNPCE) at 25 and 50 mu g/mL concentrations for 24 h and at the highest (50 mu g/mL) concentration for 48 h when compared with negative control. Also significant reduction for the polychromatic erythrocyte/normochromatic erythrocyte (PCE/NCE) ratio which is indicative for bone marrow cytotoxicity was observed at the same concentrations for 24 and 48 h. These results lead us to the conclusion that propineb may have genotoxic and cytotoxic potential due to induction in the frequency of MN and a reduction in PCE/NCE ratio in the bone marrow cells of mice.
Açıklama
WOS: 000340561000005
Anahtar Kelimeler
dithiocarbamate, fungicide, mice bone marrow cells, micronucleus assay, propineb
Kaynak
Cytology And Genetics
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
48
Sayı
4
