Effect of insulin-like growth factor-1 and hyaluronic acid in experimentally produced osteochondral defects in rats

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dc.contributor.authorAlemdar, Celil
dc.contributor.authorYücel, İstemi
dc.contributor.authorErbil, Barış
dc.contributor.authorErdem, Havva
dc.contributor.authorAtiç, Ramazan
dc.contributor.authorÖzkul, Emin
dc.date.accessioned2020-05-01T09:11:41Z
dc.date.available2020-05-01T09:11:41Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionOZKUL, EMIN/0000-0003-2149-8154en_US
dc.descriptionWOS: 000381289600012en_US
dc.descriptionPubMed: 27512224en_US
dc.description.abstractBackground: The common purpose of almost all methods used to treat the osteochondral injuries is to produce a normal cartilage matrix. However current methods are not sufficient to provide a normal cartilage matrix. For that reason, researchers have studied to increase the effectiveness of this methods using chondrogenic and chondroprotective molecules in recent experimental studies. Insulin-like growth factor-1 (IGF-1) and hyaluronic acid (HA) are two important agents used in this field. This study compared the effects of IGF-1 and HA in an experimental osteochondral defect in rat femora. Materials and Methods: The rats were divided into three groups ( n = 15 per group) as follows: The IGF-1 group, HA group, and control group. An osteochondral defect of a diameter of 1.5 mm and a depth of 2 mm was created on the patellar joint side of femoral condyles. The IGF-1 group received an absorbable gelatin sponge soaked with 15 g/15 l of IGF-1, and the HA group received an absorbable gelatin sponge soaked with 80 g HA. The control group received only an absorbable gelatin sponge. Rats were sacrificed at the 6 (th) week, and the femur condyles were evaluated histologically. Results: According to the total Mankin scale, there was a statistically significant difference between IGF-1 and HA groups and between IGF-1 and control groups. There was also a significant statistical difference between HA and control groups. Conclusion: It was shown histopathologically that IGF-1 is an effective molecule for osteochondral lesions. Although it is weaker than IGF-1, HA also strengthened the repair tissue.en_US
dc.identifier.doi10.4103/0019-5413.185607en_US
dc.identifier.endpage420en_US
dc.identifier.issn0019-5413
dc.identifier.issn1998-3727
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage414en_US
dc.identifier.urihttps://doi.org/10.4103/0019-5413.185607
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5724
dc.identifier.volume50en_US
dc.identifier.wosWOS:000381289600012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofIndian Journal Of Orthopaedicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCartilageen_US
dc.subjecthyaluronic aciden_US
dc.subjectinsulin-like growth factor-1en_US
dc.subjectosteochondral defect MeSH terms: Hyaluronic aciden_US
dc.subjectcartilageen_US
dc.subjectIGF-1en_US
dc.subjectsports medicineen_US
dc.subjectratsen_US
dc.titleEffect of insulin-like growth factor-1 and hyaluronic acid in experimentally produced osteochondral defects in ratsen_US
dc.typeArticleen_US

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