Alterations in placental pendrin expression in pre-eclampsia

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dc.contributor.authorKarataş, Ahmet
dc.contributor.authorErdem, Havva
dc.contributor.authorAlbayrak, Mustafa
dc.contributor.authorOktay, Murat
dc.contributor.authorÖzlü, Tülay
dc.contributor.authorÇakmak, Bülent
dc.contributor.authorDönmez, Melahat Emine
dc.date.accessioned2020-04-30T22:39:05Z
dc.date.available2020-04-30T22:39:05Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionoktay, murat/0000-0002-0893-4444;en_US
dc.descriptionWOS: 000333583100007en_US
dc.descriptionPubMed: 23941406en_US
dc.description.abstractIntroduction: Pendrin is an integral membrane protein and plays a key role in extracellular fluid volume and blood pressure control. We aimed to investigate the relationship between pendrin immunostaining intensity in normal and pre-eclamptic placental tissue. Methods: Fifty-six placental tissues, of which 26 were in pre-eclamptic, and 30 were in control group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Results: There was more positive immunstaining in the pre-eclamptic placenta compared to the controls (p<0.001). A significant positive correlation was observed between immunostaining level and diastolic blood pressure (r = 0.533, p = 0.005) in the pre-eclamptic group. However, no significant correlation was observed between any condition and immunostaining level in the control group. Conclusions: Placentas in the pre-eclamptic group were significantly more immunostained with pendrin than were those in the control group. In addition, a positive correlation between immunostaining intensity with pendrin and both systolic and diastolic blood pressure were observed. Pendrin may play a role in the mechanism of severe hypertension in women with pre-eclampsia.en_US
dc.identifier.doi10.3109/14767058.2013.833600en_US
dc.identifier.endpage690en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage687en_US
dc.identifier.urihttps://doi.org/10.3109/14767058.2013.833600
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2591
dc.identifier.volume27en_US
dc.identifier.wosWOS:000333583100007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofJournal Of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPendrinen_US
dc.subjectplacentaen_US
dc.subjectpre-eclampsiaen_US
dc.titleAlterations in placental pendrin expression in pre-eclampsiaen_US
dc.typeArticleen_US

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