Resistin predicts ischemia in myocardial perfusion scintigraphy

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dc.contributor.authorYıldırım, Mustafa
dc.contributor.authorErkan, Melih Engin
dc.contributor.authorAşık, Muhammet
dc.contributor.authorUçgun, Taner
dc.contributor.authorYılmaz, Ayşe
dc.contributor.authorİlçe, Huri Tilla
dc.contributor.authorDoğan, Ahmet Semih
dc.date.accessioned2020-04-30T23:31:40Z
dc.date.available2020-04-30T23:31:40Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000334063700024en_US
dc.descriptionPubMed: 25558655en_US
dc.description.abstractAim: Resistin plays a role in the pathogenesis of coronary artery disease and is related to mortality and morbidity through a number of mechanisms. We hypothesize that plasma resistin levels are increased in the presence of ischemia, as measured by GATED single-photon emission computed tomography myocardial perfusion scintigraphy (SPECT MPS), in comparison with nonischemic subjects. Materials and methods: Fasting intravenous blood samples of patients were drawn before a stress test. An ELISA kit was used for the assays. All patients underwent a technetium 99m-sestamibi GATED SPECT MPS study with a 1-day stress-rest protocol. Images were analyzed visually and patients were assessed as ischemic or nonischemic. Resistin levels were presented as medians (25th-75th percentiles) and were compared using the Mann-Whitney U test. Results: Plasma resistin levels were higher in the ischemic group (n = 47) than in the nonischemic group (n = 67) [9.04 mu mol/L (6.27-11.8 mu mol/L) vs. 3.56 mu mol/L (0.39-7.93 mu mol/L), respectively; P < 0.001). We showed that plasma resistin levels (OR = 1.26, 95% CI: 1.13-1.41; P < 0.001) and METs (OR = 0.82, 95% CI: 0.70-0.92; P = 0.021) were independent predictors of ischemia. No linear correlation was found between plasma resistin levels and GATED SPECT or stress test parameters. Conclusion: Increased baseline resistin levels are independently related to presence of ischemia but are not related to the extent or severity of ischemia, or other functional parameters such as poststress ejection fraction, end systolic, and end diastolic volumes.en_US
dc.identifier.doi10.3906/sag-1302-146en_US
dc.identifier.endpage500en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage496en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1302-146
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4391
dc.identifier.volume44en_US
dc.identifier.wosWOS:000334063700024en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectResistinen_US
dc.subjectmyocardial perfusion scintigraphyen_US
dc.subjectischemiaen_US
dc.titleResistin predicts ischemia in myocardial perfusion scintigraphyen_US
dc.typeArticleen_US

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