Effect of diabetic kidney disease on sarcopenia and quality of life in patients with type 1 diabetes

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dc.contributor.authorDaloglu, Osman Onur
dc.contributor.authorGuller, Pinar Uzgec
dc.contributor.authorAlak, Zehra Yagmur Sahin
dc.contributor.authorGuclu, Metin
dc.contributor.authorKiyici, Sinem
dc.date.accessioned2025-10-11T20:48:44Z
dc.date.available2025-10-11T20:48:44Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractPurpose Sarcopenia can develop at a younger age as a complication in patients with type 1 diabetes (T1D). This study aimed to evaluate the association of sarcopenia with diabetic kidney disease (DKD) in non-elderly patients with T1D. Methods This cross-sectional study enrolled 100 patients with T1D, including 50 individuals with DKD and 50 without. Median age of patients was 31 years (25-75th percentile: 24.2-44) and a median duration of T1D was 10.1 years (25-75th percentile: 9-13). Hand grip strength (HGS), skeletal muscle mass index (SMMI) were utilized to assess the presence of sarcopenia. The Sarcopenia Quality of Life (SarQoL) and Pittsburgh Sleep Quality questionnaires were used to evaluate the quality of life. Results Sarcopenia was diagnosed in 19 out of 100 patients (19%). The prevalence of sarcopenia was 36% (18 out of 50) in the DKD group and 2% (1 out of 50) in the non-DKD group. Sarcopenia was more prevalent in the DKD group (p < 0.001). Urinary albumin-to-creatinine ratio (UACR) levels were a significant predictor of sarcopenia (odds ratio 1.031, 95% CI 1.009-1.058; p = 0.005). The median HGS and SMMI values were lower in the sarcopenia group than in the non-DKD group (p = 0.006 and p = 0.001 respectively). Furthermore, the SarQol scores and sleep quality were lower in the sarcopenia group compered to the non-DKD group (p = 0.018 and p < 0.05, respectively). Conclusions Sarcopenia may occur earlier in non-elderly patients with T1D and DKD, adversely affecting the quality of life. Early screening for sarcopenia should be considered in individuals with DKD.en_US
dc.description.sponsorshipSociety of Endocrinology and Metabolism of Turkeyen_US
dc.description.sponsorshipWe express our gratitude to our patients for their willingness to share their clinical data for publication. Preparation for the publication of this article was supported by the Society of Endocrinology and Metabolism of Turkey.en_US
dc.identifier.doi10.1007/s12020-025-04395-5
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.pmid40835810en_US
dc.identifier.scopus2-s2.0-105013541477en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-025-04395-5
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22049
dc.identifier.wosWOS:001554545700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectType 1 diabetesen_US
dc.subjectSarcopeniaen_US
dc.subjectDiabetic kidney diseaseen_US
dc.subjectSarcopenia quality of lifeen_US
dc.titleEffect of diabetic kidney disease on sarcopenia and quality of life in patients with type 1 diabetesen_US
dc.typeArticleen_US

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