Abdominal obesity with hypertriglyceridaemia, lipoprotein(a) and apolipoprotein A-I determine marked cardiometabolic risk

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dc.contributor.authorOnat, Altan
dc.contributor.authorCan, Günay
dc.contributor.authorÖrnek, Ender
dc.contributor.authorSansoy, Vedat
dc.contributor.authorAydın, Mesut
dc.contributor.authorYüksel, Hüsniye
dc.date.accessioned2020-04-30T22:38:55Z
dc.date.available2020-04-30T22:38:55Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionornek, ender/0000-0002-5233-8658; Sansoy, Vedat/0000-0001-7571-7039en_US
dc.descriptionWOS: 000325547000004en_US
dc.descriptionPubMed: 24020867en_US
dc.description.abstractBackground Risks for coronary heart disease (CHD) and diabetes (T2DM) of the hypertriglyceridemic waist' phenotype (HtgW) warrant further investigation. We studied this issue and whether partial proinflammatory conversion of apolipoprotein (apo) A-I by lipoprotein(a) [Lp(a)] is a codeterminant. Materials and Methods In a population-based prospective study, 1328 Turkish adults were analysed in four groups by the presence of abdominal obesity and elevated triglycerides (Htg). Results LDL-cholesterol levels, significantly elevated in isolated Htg, were lower in HtgW, yet significantly higher apoB and complement C3 values existed in women with HtgW in whom also the lowest Lp(a) values prevailed. Lp(a) was linearly associated, more strongly in HtgW than in the remaining groups, with apoB and, in women inversely, with gamma-glutamyltransferase. Incident HtgW was predicted, not in men, but in women inversely by Lp(a) (OR 0 center dot 80 [95%CI 0 center dot 65; 0 center dot 97]), regardless of adjustment for relevant confounders. After adjustment for conventional risk factors, HtgW (OR 2 center dot 84) and high apoA-I/HDL-C ratio (OR 1 center dot 50) were significantly and additively associated with combined prevalent and incident CHD risk. High apoA-I and low HDL-cholesterol levels interacted therein in women. Type-2 diabetes was strongly predicted by HtgW, mediated in men by high apoA-I/HDL-C ratio. Conclusion HtgW is associated with excess inflammatory markers, is predicted in women paradoxically by lower circulating Lp(a) and is associated in both sexes with marked excess cardiometabolic risk to which high apoA-I/HDL-C ratio contributes additively. These findings are consistent in women with apoA-I being oxidized via aggregation to Lp(a).en_US
dc.description.sponsorshipTurkish Society of Cardiologyen_US
dc.description.sponsorshipThe Turkish Society of Cardiology is gratefully acknowledged for its support to the Turkish Adult Risk Factor study. We appreciate the dedicated work of past members in the survey teams.en_US
dc.identifier.doi10.1111/eci.12150en_US
dc.identifier.endpage1139en_US
dc.identifier.issn0014-2972
dc.identifier.issn1365-2362
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1129en_US
dc.identifier.urihttps://doi.org/10.1111/eci.12150
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2516
dc.identifier.volume43en_US
dc.identifier.wosWOS:000325547000004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEuropean Journal Of Clinical Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbdominal obesityen_US
dc.subjectcoronary heart diseaseen_US
dc.subjectgender differenceen_US
dc.subject"hypertriglyceridemic waist' phenotypeen_US
dc.subjectlipoprotein(a)-apolipoprotein A-Ien_US
dc.titleAbdominal obesity with hypertriglyceridaemia, lipoprotein(a) and apolipoprotein A-I determine marked cardiometabolic risken_US
dc.typeArticleen_US

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