The role of argyrophilic nucleolar organizing region-associated proteins in clinical exacerbation of chronic obstructive pulmonary disease

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dc.contributor.authorSönmez, Feruza Turan
dc.contributor.authorEröz, Recep
dc.date.accessioned2020-04-30T23:34:25Z
dc.date.available2020-04-30T23:34:25Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionTURAN SONMEZ, Feruza/0000-0001-8817-8521en_US
dc.descriptionWOS: 000453601300014en_US
dc.descriptionPubMed: 30088791en_US
dc.description.abstractObjective To investigate whether argyrophilic nucleolar organizing region-associated protein (AgNOR) parameters can be used as a biomarker that could potentially help with the management and clinical prognosis of chronic obstructive pulmonary disease (COPD) exacerbation. Methods This case-control study enrolled patients with COPD who were admitted to the Emergency Department and healthy sex- and age-matched control subjects. Peripheral blood samples were collected at hospital admission and the peripheral lymphocytes were silver-stained to investigate the quantity and distribution of AgNOR proteins. Fifty nuclei per patient were viewed and the total AgNOR area/total nuclear area (TAA/TNA) ratio and the mean AgNOR number for each patient were calculated. Results A total of 20 patients with COPD exacerbation and 17 healthy control subjects were recruited to the study. The TAA/TNA ratio and the mean AgNOR number were significantly higher in the patients with COPD exacerbation compared with the healthy control subjects. The mean AgNOR number showed a positive correlation with the pCO(2) levels on admission. Conclusion AgNOR protein levels were elevated during a COPD exacerbation compared with healthy control subjects and there was a positive correlation between pCO(2) levels and mean AgNOR number.en_US
dc.identifier.doi10.1177/0300060518788751en_US
dc.identifier.endpage5003en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage4995en_US
dc.identifier.urihttps://doi.org/10.1177/0300060518788751
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5161
dc.identifier.volume46en_US
dc.identifier.wosWOS:000453601300014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal Of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectargyrophilic nucleolar organizing region-associated proteinsen_US
dc.subjectexacerbationen_US
dc.subjectmanagementen_US
dc.subjectmarkeren_US
dc.titleThe role of argyrophilic nucleolar organizing region-associated proteins in clinical exacerbation of chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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