Assessment of serum oxidative stress parameters in migraine patients

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dc.authoridCakici, Cagri/0000-0002-8662-5284;
dc.contributor.authorUlfer, Gozde
dc.contributor.authorPolat, Burcu
dc.contributor.authorYabalak, Ahmet
dc.contributor.authorCakici, Cagri
dc.date.accessioned2025-10-11T20:48:23Z
dc.date.available2025-10-11T20:48:23Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjectives This study was conducted to evaluate the correlation between serum oxidative stress parameters and clinical characteristics of patients with migraine by measuring total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), ischemia- modified albumin (IMA), and thiol/disulfide homeostasis levels. Materials and Methods The study included a total of 152 individuals, of whom 76 were diagnosed with migraine and 76 were controls. Disease duration, attack duration, attack frequency, Visual Analog Scale scores, comorbidities, were recorded in the migraine group. Using the serum samples of the patient and control groups, oxidative stress parameters were analyzed by colorimetric methods and evaluated together with clinical findings. Results In the patient group, the measured total thiol, native thiol, IMA, TOS, and OSI levels were statistically significantly higher than those in the control group (for each group; p < 0.01). The mean TAS level of the patient group was significantly lower than that of the control group (p < 0.01). A significant positive correlation was found between the frequency of attacks and the measured IMA levels (r: 0.244; p = 0.034; p < 0.05). Conclusions This study found that TAS levels decreased, while TOS, OSI, and IMA levels increased during the interictal period in patients with migraine. These parameters shifting toward an oxidant balance may indicate that oxidative stress also plays a role in the pathogenesis of migraine. In addition, the significant positive correlation between the frequency of attacks and IMA levels are likely to indicate that secondary ischemic mechanisms may play a role in the pathophysiology of this condition.en_US
dc.identifier.doi10.1080/01616412.2025.2483873
dc.identifier.endpage465en_US
dc.identifier.issn0161-6412
dc.identifier.issn1743-1328
dc.identifier.issue6en_US
dc.identifier.pmid40169171en_US
dc.identifier.scopus2-s2.0-105002063344en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.1080/01616412.2025.2483873
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21887
dc.identifier.volume47en_US
dc.identifier.wosWOS:001457222000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNeurological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectMigraineen_US
dc.subjecttotal antioxidant statusen_US
dc.subjecttotal oxidant statusen_US
dc.subjectischemia-modified albuminen_US
dc.subjectthiol/disulfide homeostasisen_US
dc.titleAssessment of serum oxidative stress parameters in migraine patientsen_US
dc.typeArticleen_US

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