Subclinical right ventricular dysfunction in intermittent and persistent mildly asthmatic children on tissue Doppler echocardiography and serum NT-proBNP: Observational study

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dc.contributor.authorÖzde, Cem
dc.contributor.authorDoğru, Mahmut
dc.contributor.authorÖzde, Şükriye
dc.contributor.authorKayapınar, Osman
dc.contributor.authorKaya, Adnan
dc.contributor.authorKorkmaz, Ahmet
dc.date.accessioned2020-04-30T23:32:17Z
dc.date.available2020-04-30T23:32:17Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionkaya, adnan/0000-0002-9225-8353en_US
dc.descriptionWOS: 000489002900007en_US
dc.descriptionPubMed: 30179288en_US
dc.description.abstractBackground Bronchial asthma may lead to pulmonary hypertension, right ventricular (RV) dysfunction, and cor pulmonale due to elevated afterload on the RV later in life. The aim of this study was to determine whether serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) might serve as a biomarker for detecting subclinical RV dysfunction using echocardiography during the early stages of bronchial asthma. Methods Sixty-eight pediatric patients with asthma (asthma group) and 69 age- and sex-matched healthy children (control group) were enrolled. The study was conducted in a tertiary woman and child diseases education and research hospital from January 2013 to December 2013. RV function (2-D and tissue-Doppler echocardiography), pulmonary function (spirometry) and serum NT-proBNP concentration were evaluated. Results Mean age was 10.5 +/- 2.8 years in the asthma group and 10.2 +/- 2.7 years in the control group (P = 0.522). RV diastolic function was significantly decreased in the asthma group (ratio of tricuspid lateral annular early diastolic peak velocity to tricuspid lateral annular late diastolic peak velocity [E '/A '], 1.29 +/- 0.68 vs 1.74 +/- 0.89, P = 0.001). RV myocardial performance index was significantly higher in the asthma group than in the control group (0.28 +/- 0.06 vs 0.24 +/- 0.07, respectively; P = 0.003). Finally, serum NT-proBNP concentration was significantly higher in the asthma group than in the control group (292.3 +/- 142.2 pg/mL vs 208.2 +/- 70.1 pg/mL, respectively; P = 0.003). Conclusion Increased serum NT-proBNP is associated with subclinical RV dysfunction in asthmatic children. RV function is significantly affected in children with bronchial asthma.en_US
dc.identifier.doi10.1111/ped.13689en_US
dc.identifier.endpage1032en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1024en_US
dc.identifier.urihttps://doi.org/10.1111/ped.13689
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4670
dc.identifier.volume60en_US
dc.identifier.wosWOS:000489002900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectasthmaen_US
dc.subjectchildrenen_US
dc.subjectN-terminal pro-B-type natriuretic peptideen_US
dc.subjectsubclinical right ventricular dysfunctionen_US
dc.titleSubclinical right ventricular dysfunction in intermittent and persistent mildly asthmatic children on tissue Doppler echocardiography and serum NT-proBNP: Observational studyen_US
dc.typeArticleen_US

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