Measurement of epidermal thickness in a patient with psoriasis by computer-supported image analysis

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dc.contributor.authorAlper, Murat
dc.contributor.authorKavak, Ayşe
dc.contributor.authorParlak, Ali Haydar
dc.contributor.authorDemirci, Recep
dc.contributor.authorBelenli, İbrahim
dc.contributor.authorYeşildal, Nuray
dc.date.accessioned2020-04-30T13:32:45Z
dc.date.available2020-04-30T13:32:45Z
dc.date.issued2004
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionPubMed ID: 14689051en_US
dc.description.abstractThe aim of the present study was to measure full epidermal thickness, stratum corneum thickness, rete length, dermal papilla widening and suprapapillary epidermal thickness in psoriasis patients using a light microscope and computer-supported image analysis. The data obtained were analyzed in terms of patient age, type of psoriasis, total body surface area involvement, scalp and nail involvement, duration of psoriasis, and family history of the disease. The study was conducted on 64 patients and 57 controls whose skin biopsies were examined by light microscopy. The acquired microscopic images were transferred to a computer and measurements were made using image analysis. The skin biopsies, taken from different body areas, were examined for different parameters such as epidermal, corneal and suprapapillary epidermal thickness. The most prominent increase in thickness was detected in the palmar region. Corneal thickness was more pronounced in patients with scalp involvement than in patients without scalp involvement (t = -2.651, P = 0.008). The most prominent increase in rete length was observed in the knees (median: 491 ?m, t = 10.117, P = 0.000). The difference in rete length between patients with a positive and a negative family history was significant (t = -3.334, P = 0.03), being 27% greater in psoriasis patients without a family history. The differences in dermal papilla distances among patients were very small. We conclude that microscope-supported thickness measurements provide objective results.en_US
dc.identifier.doi10.1590/S0100-879X2004000100015en_US
dc.identifier.endpage117en_US
dc.identifier.issn0100879X
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://dx.doi.org/10.1590/S0100-879X2004000100015
dc.identifier.urihttps://hdl.handle.net/20.500.12684/427
dc.identifier.volume37en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssociacao Brasileira de Divulgacao Cientificaen_US
dc.relation.ispartofBrazilian Journal of Medical and Biological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectComputer-supported image-analysis; Epidermis; Psoriasis; Thicknessen_US
dc.titleMeasurement of epidermal thickness in a patient with psoriasis by computer-supported image analysisen_US
dc.typeArticleen_US

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