Evaluation of whole blood thiamine pyrophosphate concentrations in critically ill patients receiving chronic diuretic therapy prior to admission to Turkish intensive care units: A pragmatic, multicenter, prospective study

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dc.authoridOzyilmaz, Ezgi/0000-0002-4535-705Xen_US
dc.authoridErgün, Recai/0000-0002-6702-9188en_US
dc.authoridErgün, Recai/0000-0002-6702-9188en_US
dc.authoridSungur, Murat/0000-0002-0011-3166en_US
dc.authoridcankar dal, hayriye/0000-0003-4744-9959en_US
dc.authoridAYDIN, KANİYE/0000-0001-5538-3692en_US
dc.authoridDizdar, Oguzhan/0000-0001-9259-7024en_US
dc.authorscopusid6507293365en_US
dc.authorscopusid57212001095en_US
dc.authorscopusid57772642900en_US
dc.authorscopusid57212005094en_US
dc.authorscopusid57204654693en_US
dc.authorscopusid22133297600en_US
dc.authorscopusid58246406800en_US
dc.authorwosidOzyilmaz, Ezgi/U-9917-2018en_US
dc.authorwosidGundogan, Kursat/KMA-2084-2024en_US
dc.authorwosidErgün, Recai/I-6172-2018en_US
dc.authorwosidÖzer, Nurhayat Tuğra/JXL-6285-2024en_US
dc.authorwosidErgün, Recai/HKM-3600-2023en_US
dc.authorwosidSungur, Murat/AAU-5564-2020en_US
dc.authorwosidcankar dal, hayriye/ABP-0759-2022en_US
dc.contributor.authorGundogan, Kursat
dc.contributor.authorSahin, Gulsah G.
dc.contributor.authorErgul, Serap S.
dc.contributor.authorOzer, Nurhayat T.
dc.contributor.authorTemel, Sahin
dc.contributor.authorAkbas, Turkay
dc.contributor.authorErcan, Talha
dc.date.accessioned2024-08-23T16:04:42Z
dc.date.available2024-08-23T16:04:42Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground/Objectives: Thiamine plays a pivotal role in energy metabolism. The aim of the study was to deter-mine serial whole blood TPP concentrations in critically ill patients receiving chronic diuretic treatment before ICU admission and to correlate TPP levels with clinically determined serum phosphorus concentrations.Subjects/Methods: This observational study was performed in 15 medical ICUs. Serial whole blood TPP concen-trations were measured by HPLC at baseline and at days 2, 5 and 10 after ICU admission. Results: A total of 221 participants were included. Of these, 18% demonstrated low TPP concentrations upon admission to the ICU, while 26% of participants demonstrated low levels at some point during the 10-day study period. Hypophosphatemia was detected in 30% of participants at some point during the 10-day period of observation. TPP levels were significantly and positively correlated with serum phosphorus levels at each time point (P < 0.05 for all).Conclusions: Our results show that 18% of these critically ill patients exhibited low whole blood TPP concen-trations on ICU admission and 26% had low levels during the initial 10 ICU days, respectively. The modest correlation between TPP and phosphorus concentrations suggests a possible association due to a refeeding effect in ICU patients requiring chronic diuretic therapy.en_US
dc.description.sponsorshipErciyes University Scientific Research Committee [THD-2020- 10295]; Turkish Society of Clinical Enteral & Parenteral Nutrition (KEPAN)en_US
dc.description.sponsorshipErciyes University Scientific Research Committee (THD-2020- 10295) and Turkish Society of Clinical Enteral & Parenteral Nutrition (KEPAN) to KG.en_US
dc.identifier.doi10.1016/j.jcrc.2023.154326
dc.identifier.issn0883-9441
dc.identifier.issn1557-8615
dc.identifier.pmid37186999en_US
dc.identifier.scopus2-s2.0-85159090175en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcrc.2023.154326
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14319
dc.identifier.volume77en_US
dc.identifier.wosWOS:001010698900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Critical Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCritical illnessen_US
dc.subjectDiureticsen_US
dc.subjectRefeeding syndromeen_US
dc.subjectThiamineen_US
dc.subjectDeficiencyen_US
dc.subjectEncephalopathyen_US
dc.subjectMortalityen_US
dc.subjectScoreen_US
dc.titleEvaluation of whole blood thiamine pyrophosphate concentrations in critically ill patients receiving chronic diuretic therapy prior to admission to Turkish intensive care units: A pragmatic, multicenter, prospective studyen_US
dc.typeArticleen_US

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