The effects of acetyl shikonin isolated from Onosma armeniacum on oxidative stress in ethanol-induced ulcer model of rats

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dc.contributor.authorToker, Aysun
dc.contributor.authorAkçay, Fatih
dc.contributor.authorAksoy, Hülya
dc.contributor.authorSüleyman, Halis
dc.contributor.authorÖzgen, Ufuk
dc.contributor.authorErdem, Havva
dc.date.accessioned2020-04-30T23:33:17Z
dc.date.available2020-04-30T23:33:17Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000321227500024en_US
dc.description.abstractAim: We investigated the effects of acetyl shikonin isolated from Onosma armeniacum on ethanol-induced gastric injury (ulcer) and on oxidant antioxidant parameters in the gastric tissue of rats. Materials and methods: Eighteen albino Wistar male rats were divided into 3 different experimental groups. Group 1 (n = 6) was the control group, group 2 (n = 6) was the ethanol group, and group 3 (n = 6) was the acetyl shikonin + ethanol group. The animals in group 3 were given ethanol (1 mL, 50% v/v) 30 min after acetyl shikonin (40 mg/kg) administration by orogastric tube. Results: The lowest mean nitric oxide level; the lowest superoxide dismutase, glutathione peroxidase, and glutathione S-transferase activities; and the highest malondialdehyde level and myeloperoxidase activity were obtained in group 2. It was observed that acetyl shikonin increased the activities of antioxidant enzymes and the level of nitric oxide and decreased the level of malondialdehyde and the activity of myeloperoxidase in group 3. In histopathological evaluation, minimal lymphocyte infiltration and edema were seen but no ulcerations were observed in group 3. Conclusion: The data revealed that the antiulcer effect of acetyl shikonin might be due to an increase in antioxidant enzyme activity and nitric oxide levels, and a decrease in malondialdehyde levels and myeloperoxidase activity.en_US
dc.identifier.doi10.3906/sag-1203-89en_US
dc.identifier.endpage320en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage315en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1203-89
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4936
dc.identifier.volume43en_US
dc.identifier.wosWOS:000321227500024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetyl shikoninen_US
dc.subjectoxidative stressen_US
dc.subjectethanol-induced ulceren_US
dc.titleThe effects of acetyl shikonin isolated from Onosma armeniacum on oxidative stress in ethanol-induced ulcer model of ratsen_US
dc.typeArticleen_US

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