Increased P wave duration in patients with depression or anxiety disorder
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Medknow Publications & Media Pvt Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
BACKGROUND: Activation of the sympathetic nervous system plays an important role in regulating cardiovascular actions. P wave parameters can provide general information on central cardiovascular autonomic regulatory responses, which are altered in patients with anxiety disorders and depression. In particular, there are no reports addressing changes in P wave duration and dispersion. OBJECTIVE: To compare the differences in P wave duration and P wave dispersion between patients with anxiety disorders and depression, because patients with anxiety disorders and depression develop abnormal electrocardiograms. DESIGN, TIME AND SETTING: A non-randomized concurrent controlled study was performed. Patients with depression and general anxiety disorders were admitted at the psychiatry outpatient clinics of the Medical Faculty of Duzce University of Turkey between May 2005 and October 2006. PARTICIPANTS: A total of 71 consecutive patients with depression and anxiety disorders, as well as 50 physically and mentally healthy age-and gender-matched controls were selected. METHODS: Electrocardiogram records were obtained at the time of admission to the outpatient clinics. MAIN OUTCOME MEASURES: P wave duration and P wave dispersion were measured. RESULTS: Both the maximum (P-max) and minimum (P-min) P wave duration were greater in patients with psychiatric disorders than in healthy controls. P-max was significantly greater in patients with depression or anxiety disorders (Bonferroni test, P < 0.017). The P wave dispersion was similar between patients and controls (P > 0.017). P waves were similar between panic patients and other anxiety patients. Beck depression results were positively correlated with P-min and P-max (r = 0.374, 0.302, P = 0.013, 0.049, respectively), and not associated with P wave dispersion (P > 0.05). CONCLUSION: Psychiatric disorders are associated with increases in P-max, but not with P wave dispersion. The P wave changes were associated with the degree of depression.
Açıklama
Kocer, Abdulkadir/0000-0003-2866-555X; Alcelik, Aytekin/0000-0002-3156-1076
WOS: 000277425100011
WOS: 000277425100011
Anahtar Kelimeler
P wave, depression, anxiety, panic disorder, scales, sympathetic modulation, electrocardiogram, P wave duration, P wave dispersion
Kaynak
Neural Regeneration Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
5
Sayı
7
