Association Between Survivin Gene Polymorphisms and the Susceptibility to Colon Cancer Development in the Turkish Population

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dc.contributor.authorYamak, Nesibe
dc.contributor.authorYaykaşlı, Kürşat Oğuz
dc.contributor.authorYılmaz, Ümit
dc.contributor.authorEröz, Recep
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorBaltacı, Davut
dc.date.accessioned2020-04-30T22:39:51Z
dc.date.available2020-04-30T22:39:51Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Handan Camdeviren/0000-0002-3613-0523; Yaykasli, Kursat/0000-0001-7550-6370en_US
dc.descriptionWOS: 000351055100074en_US
dc.descriptionPubMed: 25374237en_US
dc.description.abstractBackground: Colon cancer is one of the most common cancers worldwide. Apoptosis is a necessary physiological process for cell elimination which is very important both cellular homeostasis and cell proliferation and differantiation. Dysregulation can lead to uncontrolled cell growth and tumor development. Survivin, a member of the IAP family, plays a key role in promotion of cell proliferation as well as inhibition of apoptosis in cancer cells. The aim of this study was to investigate whether specific genetic polymorphisms of survivin could be associated with colon cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between colon cancer risk and survivin gene polymorphisms. Materials and Methods: The relation between colon cancer and survivin -31 G/C (rs9904341), -241 C/T (rs17878467) and -625 C/G (rs8073069) polymorphism in promotor site of survivin gene associated with apoptosis was investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Individuals with -31C allele and CC genotype were found to have a higher risk of developing colon cancer (OR=13.4, p=0.01). The -241 CT genotype considerably increased the risk of colon cancer (OR=12.0, p=0.0001). However, there was no significant varaition of the survivin -625 C/G polymorphism among colon cancer patients and controls in our study. Conclusions: This study provides the first evidence that survivin -31 G/C and -241 C/T SNP significantly contribute to the risk of colon cancer in the Turkish population.en_US
dc.identifier.doi10.7314/APJCP.2014.15.20.8963en_US
dc.identifier.endpage8967en_US
dc.identifier.issn1513-7368
dc.identifier.issue20en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage8963en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2014.15.20.8963
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2845
dc.identifier.volume15en_US
dc.identifier.wosWOS:000351055100074en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal Of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColon canceren_US
dc.subjectsurvivinen_US
dc.subjectpolymorphismen_US
dc.subjectPCR-RFLPen_US
dc.subjectsusceptibilityen_US
dc.subjectTurkeyen_US
dc.titleAssociation Between Survivin Gene Polymorphisms and the Susceptibility to Colon Cancer Development in the Turkish Populationen_US
dc.typeArticleen_US

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