Posterior sub-tenon's capsule triamcinolone injection combined with focal laser photocoagulation for diabetic macular edema

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dc.contributor.authorTunç, Murat
dc.contributor.authorÖnder, Halil İbrahim
dc.contributor.authorKaya, Murat
dc.date.accessioned2020-04-30T23:21:09Z
dc.date.available2020-04-30T23:21:09Z
dc.date.issued2005
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionJoint Meeting of the American-Academy-of-Ophthalmology/European-Society-of-Ophthalmology -- 38264 -- New Orleans, LAen_US
dc.descriptionWOS: 000229531400022en_US
dc.descriptionPubMed: 15885789en_US
dc.description.abstractPurpose: To investigate the efficacy of posterior sub-Tenon's capsule triamcinolone injection (PSTI) combined with focal laser (FL) photocoagulation in treatment of diffuse clinically significant diabetic macular edema (CSME). Design: Prospective randomized clinical study. Participants: Sixty patients with diffuse CSME. Methods: We randomized the patients who had CSME into 2 treatment groups. A total of 30 eyes received macular focal and grid laser photocoagulation (MP), and the second group of 30 eyes received FL photocoagulation combined with PSTI (FL + PSTI). Clinical and visual evaluations were performed at baseline and 12 and 18 weeks after treatment, and the results were compared by statistical methods. Mean Outcome Measures: Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity (VA) scores and clinical changes in macular edema. Results: Before treatment, mean ETDRS VA scores were 45.9 +/- 12.7 (mean +/- standard deviation [SD]; range, 24-66) in MP (focal + grid laser) and 44.5 +/- 12.6 (range, 22-66) in the FL + PSTI group. Early Treatment Diabetic Retinopathy Study scores at 18 weeks were 46.4 +/- 14.2 (range, 20-70) after MP and 52.5 +/- 17.5 (range, 22-82) after FL + PSTI. Early Treatment Diabetic Retinopathy Study scores significantly improved in eyes that received FL + PSTI (P = 0.0001, paired t test). The FL + PSTI group had an increase of 12.4 +/- 7.1 (range, 5-26) ETDRS letters, and the MP group had an increase of 7.8 +/- 3.1 (range, 5-15) letters (P = 0.04, unpaired t test). Twelve of 30 (40%) cases in the MP group and 24 of 30 (80%) cases in the FL + PSTI group showed clinical improvement in macular edema according to the stereoscopic evaluation of fundus and fluorescein angiography (P = 0.003). Conclusion: Posterior sub-Tenon's capsule application of triamcinolone may improve early visual outcome in diffuse diabetic macular edema when combined with FL photocoagulation.en_US
dc.description.sponsorshipAmer Acad Ophthalmol, European Soc Ophthalmolen_US
dc.identifier.doi10.1016/j.ophtha.2004.12.039en_US
dc.identifier.endpage1091en_US
dc.identifier.issn0161-6420
dc.identifier.issn1549-4713
dc.identifier.issue6en_US
dc.identifier.startpage1086en_US
dc.identifier.urihttps://doi.org/10.1016/j.ophtha.2004.12.039
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4145
dc.identifier.volume112en_US
dc.identifier.wosWOS:000229531400022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofOphthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlePosterior sub-tenon's capsule triamcinolone injection combined with focal laser photocoagulation for diabetic macular edemaen_US
dc.typeArticleen_US

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