Determination of micronuclei frequency in Danio rerio for assessing genotoxicity induced by propineb

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dc.authoridDemir, Fatma/0000-0003-3472-9863en_US
dc.authorscopusid15136582600en_US
dc.authorscopusid58814676000en_US
dc.authorscopusid8280323200en_US
dc.authorwosidDemir, Fatma/AAX-4492-2020en_US
dc.contributor.authorRasgele, Pinar Goc
dc.contributor.authorDemir, Fatma
dc.contributor.authorKirankaya, Serife Gulsun
dc.date.accessioned2024-08-23T16:04:29Z
dc.date.available2024-08-23T16:04:29Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the genotoxic effect of Propineb fungicide at different concentrations (0.167, 0.335 and 0.670 mg L-1) and different treatment times (24, 48, 72 and 96 h) on Danio rerio. At the end of the treatment periods, blood was collected from the fish with a heparin injector; smear preparations were prepared, fixed and stained. In the prepared preparations, the numbers of cells with MN and erythrocyte nucleus abnormalities were examined. It was found that propineb increased micronucleus formation at all treatment times and concentrations and induced the formation of erythrocytes with morphological abnormal nuclei such as segmented, kidney-shaped, notched, vacuolated nuclei and binucleated. The increase in micronucleus formation and the number of erythrocytes with abnormal nuclei were found to be concentration and treatment time-dependent. In conclusion, in this study, Danio rerio erythrocytes were used to evaluate the genotoxic effects of propineb fungicide on aquatic organisms, which have an important place in environmental risk assessment criteria. Since fungicides used in agricultural control such as propineb may have the potential to be genotoxic to aquatic organisms, the results of toxicity tests should be taken into consideration in the selection and use of concentrations of these chemicals.en_US
dc.identifier.doi10.1080/01480545.2024.2303970
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.pmid38225881en_US
dc.identifier.scopus2-s2.0-85182491081en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2024.2303970
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14224
dc.identifier.wosWOS:001143890500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug And Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectZebrafishen_US
dc.subjectfungicideen_US
dc.subjecttoxicityen_US
dc.subjectdithiocarbamateen_US
dc.subjectmicronucleusen_US
dc.subjectMolecular-Mechanismsen_US
dc.subjectPesticidesen_US
dc.titleDetermination of micronuclei frequency in Danio rerio for assessing genotoxicity induced by propineben_US
dc.typeArticleen_US

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