Argyrophilic nucleolar organizer regions (AgNOR) in gastric cell of obese patients with bariatric surgery
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The etiology of obesity, which is considered a pandemic, is influenced by several factors. According to the literature, gastric cells in obese patients have not been examined by silver-stained nuclueolus organizing regions (AgNOR) staining. This study investigated the relationship between obesity, nucleolus organizing region (NOR) protein synthesis, and histopathological findings. Nonobese patients undergoing gastric biopsy for various reasons and patients undergoing bariatric surgery were included. Histopathological findings, mean AgNOR count, and total AgNOR area/nuclear area ratio (TAA/NA) were evaluated for each case. In the study, 30 nonobese patients who underwent gastric biopsy and 28 patients who underwent bariatric surgery were included. Additionally, no significant differences were found in the TAA/NA ratios with respect to the presence or absence of histological activity, intestinal metaplasia, or Helicobacter pylori infection (P = .686, P = .588, and P = .069, respectively). However, a statistically significant difference in the TAA/NA ratio was observed between the patients with and without lymphocytic infiltration (P < .013). This study suggests that NOR protein synthesis is associated with lymphocytic infiltration in patients with treatment-resistant obesity. These findings may contribute to a better understanding of the underlying etiology of obesity, and should be supported by further comprehensive studies.
Açıklama
Anahtar Kelimeler
Agnor Staining, Nor Protein, Obesity, Obesity Etiology, Obesity Management
Kaynak
Medicine
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
104
Sayı
41
