Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome

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dc.contributor.authorÜnal, Mustafa
dc.contributor.authorAksoy, Duygu Yazgan
dc.contributor.authorAydın, Yusuf
dc.contributor.authorTanrıöver, Mine Durusu
dc.contributor.authorBerker, Dilek
dc.contributor.authorKarakaya, Jale
dc.contributor.authorGüler, Serdar
dc.date.accessioned2020-04-30T22:40:33Z
dc.date.available2020-04-30T22:40:33Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000337254200001en_US
dc.descriptionPubMed: 24869934en_US
dc.description.abstractBackground: Metabolic syndrome (MS) has become a pandemic in Turkey, as is the case globally. Increase in carotid artery intima-media thickness (CIMT) and erectile dysfunction (ED) may be evident before the clinical signs of cardiovascular disease appear. We aimed to investigate the prevalence of increased CIMT and ED as markers of atherosclerotic disease in patients with MS. Material/Methods: Thirty-two patients with MS and 29 healthy controls were included. Anthropometric and biochemical parameters, along with total testosterone (TT), high sensitive C-reactive protein (hs-CRP), were recorded. Carotid artery intima-media thickness was measured. Erectile dysfunction was assessed with International Index of Erectile Function. Results: Patients with MS had higher BMI, fasting plasma glucose, post-prandial plasma glucose, insulin, HOMA-IR, total cholesterol, triglycerides, hs-CRP, and CIMT, whereas TT levels were lower (p<0.0001). The prevalence and severity of erectile dysfunction were higher in patients with MS (p<0.0001). Erectile dysfunction scores correlated inversely with CIMT. MS patients with ED were older and had higher CIMT compared to those without ED. Increase in age and HOMA and decrease in TT increased the risk of ED. When KIMT exceeding the 95th percentile of healthy controls was accepted as a risk factor for CVD, presence of ED was the only determinant for this increase. Conclusions: Erectile dysfunction was more prevalent and severe in patients with MS and correlated with subclinical endothelial dysfunction. Total testosterone deficiency was prominent among MS patients. Presence of ED points to an increased risk of cardiovascular disease when MS is present.en_US
dc.identifier.endpage888en_US
dc.identifier.issn1643-3750
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage884en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3008
dc.identifier.volume20en_US
dc.identifier.wosWOS:000337254200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectErectile Dysfunctionen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.titleCarotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndromeen_US
dc.typeArticleen_US

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