Effect of a high sucrose and high fat diet in BDNF ( plus /-) mice on oxidative stress markers in adipose tissues

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dc.contributor.authorBodur, Akın
dc.contributor.authorİnce, İmran
dc.contributor.authorKahraman, Cemil
dc.contributor.authorAbidin, İsmail
dc.contributor.authorAbidin, Selcen Aydın
dc.contributor.authorAlver, Ahmet
dc.date.accessioned2020-05-01T09:11:35Z
dc.date.available2020-05-01T09:11:35Z
dc.date.issued2019
dc.departmentDÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.descriptionBodur, Akin/0000-0001-7413-2717; kahraman, cemil/0000-0002-4494-6063en_US
dc.descriptionWOS: 000464892400007en_US
dc.descriptionPubMed: 30797748en_US
dc.description.abstractThe purpose of this study was to investigate the effects of a high fat and a high sucrosediet in wild type and BDNF (+/-) mice on oxidative stress in epididymal and subcutaneousadipose tissues by measuring different markers of oxidative stress and antioxidant enzymes. Wild type (WT) and BDNF (+/-) male mice were divided into six groups receiving fed control diet (CD), high sucrose diet (HSD), or high fat diet (HFD) for four months. Levels of 3-nitrotyrosine (3-NT) increased in the HFD-fed BDNF (+/-) mice, while 4-hydroxynonenal (4-HNE) levels increased in the CD and HFD-fed BDNF (+/-) groups. Malondialdehyde (MDA) levels decreased in subcutaneous tissue compared to epididymal adipose tissue, independently of diet type. Superoxide dismutase (SOD) activity was reduced by HFD (p < 0.05), butglutathione peroxidase (GSH-Px) activity was increased by HSD in epididymal adipose tissuein BDNF (+/-) mice (p < 0.05). GSH-Px activities was increased by CD and HFD in subcutaneous adipose tissue of BDNF (+/-) (p < 0.05). SOD2 and GSH-Px3 expressions were only decreased by HSD in epididymal and subcutaneous adipose tissues of BDNF (+/-) mice (p < 0.05). In conclusion, reduced BDNF may increase OS in epididymal adipose tissue, but not in subcutaneous adipose tissue following HSD and HFD.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114S553]en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) [Grant No. 114S553].en_US
dc.identifier.doi10.1016/j.abb.2019.02.004
dc.identifier.endpage56en_US
dc.identifier.issn0003-9861
dc.identifier.issn1096-0384
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage46en_US
dc.identifier.urihttps://doi.org/10.1016/j.abb.2019.02.004
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5674
dc.identifier.volume665en_US
dc.identifier.wosWOS:000464892400007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofArchives Of Biochemistry And Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBDNFen_US
dc.subjectEpididymal adipose tissueen_US
dc.subjectSubcutaneous adipose tissueen_US
dc.subjectOxidative stressen_US
dc.subjectHigh sucrose dieten_US
dc.subjectHigh fat dieten_US
dc.titleEffect of a high sucrose and high fat diet in BDNF ( plus /-) mice on oxidative stress markers in adipose tissuesen_US
dc.typeArticleen_US

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