Synthesis, antimicrobial and antiproliferative activities of new self-assembly benzimidazole-bridged aren ruthenium rectangles in human breast cancer cells

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dc.contributor.authorOrhan, Ersin
dc.contributor.authorDülger, Görkem
dc.contributor.authorAlpay, Merve
dc.contributor.authorOksuz, Nilufer
dc.contributor.authorDülger, Başaran
dc.date.accessioned2021-12-01T18:47:11Z
dc.date.available2021-12-01T18:47:11Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractSome novel benzimidazole-bridged aren ruthenium rectangle compounds of the general structure [{Ru-2(p-cymene)(2)(mu(4)-OO boolean AND OO)}(2)(mu(4)-bbim)](4+) (bbim = 1,1 '-butyl-2-ene-di(benzimidazole) were obtained from the corresponding double-nuclear arene ruthenium compounds [Ru-2(p-cymene)(2)(mu(4)-OO boolean AND OO)Cl-2] (OO boolean AND OO = 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dichloro-1,4-benzoquinonato (dClbq), 2,5-dibromo-1,4-benzoquinonato (dBrbq), oxalato (oxa), and 5,8-dioxido-1,4-naphtoquinonato (donq) via reaction with the bbim molecule and AgCF3SO3. The antiproliferative activity and anti-cancer properties of the tetranuclear arene ruthenium compounds were evaluated against the human breast cancer cell line (MDA-231-MB). Compound 2 showed the highest antiproliferative effect among the compounds during 24- and 48-h administration. In addition, all other compounds exhibited very good cancer cell selectivity and very low micromolar cytotoxicity. The antimicrobial activities of the synthesized compounds were also determined against various test microorganisms. Evaluations were carried out using the disk diffusion method and the dilution method. In particular, the compounds exhibited more potential antibacterial effects against Gram negative bacteria than against Gram positive bacteria and showed a superior antifungal effect against Candida species. The results revealed the benzimidazole-bridged aren ruthenium rectangle compounds to be very strong and potent inhibitors.en_US
dc.description.sponsorshipScientific Research Projects Unit of Duzce UniversityDuzce University [2017.05.03.600, 2017.05.03.620]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Unit of Duzce University (Project Number: 2017.05.03.600 and 2017.05.03.620).en_US
dc.identifier.doi10.1007/s10847-021-01099-x
dc.identifier.issn1388-3127
dc.identifier.issn1573-1111
dc.identifier.scopus2-s2.0-85113810877en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1007/s10847-021-01099-x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10179
dc.identifier.wosWOS:000690696100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Inclusion Phenomena And Macrocyclic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArene rutheniumen_US
dc.subjectBisbenzimidazoleen_US
dc.subjectBioorganometallic chemistryen_US
dc.subjectAnticanceren_US
dc.subjectAntiproliferative activityen_US
dc.subjectAntimicrobial activityen_US
dc.subjectIn-Vitroen_US
dc.subjectAntitumor-Activityen_US
dc.subjectMolecular Dockingen_US
dc.subjectSchiff-Baseen_US
dc.subjectComplexen_US
dc.subjectDnaen_US
dc.subjectInhibitorsen_US
dc.subjectGrowthen_US
dc.titleSynthesis, antimicrobial and antiproliferative activities of new self-assembly benzimidazole-bridged aren ruthenium rectangles in human breast cancer cellsen_US
dc.typeArticleen_US

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