Synthesis, antimicrobial and antiproliferative activities of new self-assembly benzimidazole-bridged aren ruthenium rectangles in human breast cancer cells
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Some novel benzimidazole-bridged aren ruthenium rectangle compounds of the general structure [{Ru-2(p-cymene)(2)(mu(4)-OO boolean AND OO)}(2)(mu(4)-bbim)](4+) (bbim = 1,1 '-butyl-2-ene-di(benzimidazole) were obtained from the corresponding double-nuclear arene ruthenium compounds [Ru-2(p-cymene)(2)(mu(4)-OO boolean AND OO)Cl-2] (OO boolean AND OO = 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dichloro-1,4-benzoquinonato (dClbq), 2,5-dibromo-1,4-benzoquinonato (dBrbq), oxalato (oxa), and 5,8-dioxido-1,4-naphtoquinonato (donq) via reaction with the bbim molecule and AgCF3SO3. The antiproliferative activity and anti-cancer properties of the tetranuclear arene ruthenium compounds were evaluated against the human breast cancer cell line (MDA-231-MB). Compound 2 showed the highest antiproliferative effect among the compounds during 24- and 48-h administration. In addition, all other compounds exhibited very good cancer cell selectivity and very low micromolar cytotoxicity. The antimicrobial activities of the synthesized compounds were also determined against various test microorganisms. Evaluations were carried out using the disk diffusion method and the dilution method. In particular, the compounds exhibited more potential antibacterial effects against Gram negative bacteria than against Gram positive bacteria and showed a superior antifungal effect against Candida species. The results revealed the benzimidazole-bridged aren ruthenium rectangle compounds to be very strong and potent inhibitors.
Açıklama
Anahtar Kelimeler
Arene ruthenium, Bisbenzimidazole, Bioorganometallic chemistry, Anticancer, Antiproliferative activity, Antimicrobial activity, In-Vitro, Antitumor-Activity, Molecular Docking, Schiff-Base, Complex, Dna, Inhibitors, Growth
Kaynak
Journal Of Inclusion Phenomena And Macrocyclic Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
