Multidrug-Resistant Gram-Negative Bacteria Rate and Risk Factors in the Neonatal Intensive Care Unit: A Single-Center Ten- Year Experience

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dc.authoridCAKMAK, Hatice Mine/0000-0003-3730-0982en_US
dc.authoridAltinsoy, Hasan Baki/0000-0003-0934-3600en_US
dc.authoridYEKENKURUL, DILEK/0000-0002-4456-7485en_US
dc.authoridKocabay, Kenan/0000-0002-4030-1145en_US
dc.authorwosidCAKMAK, Hatice Mine/AFG-6839-2022en_US
dc.authorwosidAltinsoy, Hasan Baki/F-8749-2019en_US
dc.contributor.authorCakmak, Hatice Mine
dc.contributor.authorYekenkurul, Dilek
dc.contributor.authorSengun, Zehra
dc.contributor.authorYener, Selvi
dc.contributor.authorDuran, Pelin Kamuran
dc.contributor.authorDavran, Fatih
dc.contributor.authorKocabay, Kenan
dc.date.accessioned2024-08-23T16:03:50Z
dc.date.available2024-08-23T16:03:50Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: Multidrug resistance (MDR) in gram-negative neonatal infections is difficult to manage, and the risk factors differ among different studies. Therefore, we aim to investigate the demographics, mortality, MDR status of gram-negative isolates, and risk factors for MDR gram-negative infections.Methods: We conducted a retrospective single-center study about MDR gram-negative infections in neonates between January 2012-January 2022 at Duzce University Hospital in Turkey. This study evaluates neonates with MDR gram-negative infections' risk factors and clinical features. All analyses were performed using IBM SPSS V23. In addition, univariate analyses and multivariate logistic regression models were studied to determine MDR's risk factors.Results: Of 107 gram-negative bacteria, 41 (38.3%) accounted for Enterobacter, 30 (28%) for Klebsiella pneumonia, and 22 (20.6%) for Escherichia coli. Additionally, 61 (56.5%) were MDR microorganisms. Among the susceptibility tests performed for selected isolates, 41 (77.4%) had resistance to piperacillin, 57 (75%) showed resistance to amoxiclav, and 16 (72.7%) had cefoxitin resistance. In addition, carbapenemase resistance was found in 24 (43.6%) and meropenem resistance in 13 (36.1%). Colistin, aztreonam, and tigecycline resistances were the least frequent. In addition, the following dependent risk factors increased the multidrug resistance risk in gram-negative infections; late-onset sepsis 3.547 fold (p=0.005), use of mechanical ventilation 3.143 fold (p=0.007), blood transfusion 3.587 fold (p=0.013), bronchopulmonary dysplasia 6.702 fold, (p= 0.015) and total parenteral nutrition 5.591 fold (p=0.001), lower gestational age 1.122 (1/0.891) fold (p=0.026), and birth weight 1.001 (1/0.999) fold, (p=0.013). Similarly, antibiotherapy duration was significantly higher in the MDR group than in the non-MDR group.Conclusions: The reported risk factors for MDR in gram-negative neonatal infections are all dependent risk factors. Hence clinicians must be alert to all potential risk factors.en_US
dc.identifier.doi10.18521/ktd.1265336
dc.identifier.endpage235en_US
dc.identifier.issn1309-3878
dc.identifier.issue2en_US
dc.identifier.startpage228en_US
dc.identifier.trdizinid1186162en_US
dc.identifier.urihttps://doi.org/10.18521/ktd.1265336
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1186162
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13936
dc.identifier.volume15en_US
dc.identifier.wosWOS:001029516200010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofKonuralp Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGram-Negative Bacterial Infectionsen_US
dc.subjectNeonatesen_US
dc.subjectMultidrug Resistanceen_US
dc.titleMultidrug-Resistant Gram-Negative Bacteria Rate and Risk Factors in the Neonatal Intensive Care Unit: A Single-Center Ten- Year Experienceen_US
dc.typeArticleen_US

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