Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype
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Tarih
2020
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info:eu-repo/semantics/openAccess
Özet
Aim: It was aimed to evaluate the hematological inflammatory markers in treatment-naive andcomorbidity-free children and adolescents with attention deficit and hyperactivity disorder(ADHD) in this study.Material and Methods: One hundred sixty-nine children aged 6-18, who were diagnosed withADHD according to DSM-5 criteria were included in the study. Age and sex-matched 59healthy children without any psychiatric and/or medical disorder were included as a controlgroup. The children who had an intellectual disability and/or autism spectrum disorder, acute,chronic or inflammatory diseases were excluded from the study. Smoking, obesity and usingpsychotropic medications and lack of data in records were other exclusion criteria. ADHD andcontrol groups were compared in terms of sociodemographic characteristics, inflammatorymarkers and hematological parameters.Results: Mean platelet volume (MPV) and Basophil (BASO) levels were significantly higherin the ADHD group compared to the control group and this statistical difference was onlyobserved for boys. In hyperactivity subtype, red cell distribution width (RDW), lymphocyte(LYMPH) and monocytes (MONO) were higher; in attention deficit subtype mean plateletvolume-to-lymphocyte ratio (MPVLR) was higher than all other subtypes and control group.MPV was similar in three subtypes, and were higher in all of them than the control group.Conclusion: This study revealed that MPV and BASO tend to be higher in the ADHD groupespecially in boys. Hematological biomarkers may be useful for diagnosis of ADHD anddetermination of ADHD subtypes but data on this subject are insufficient and morecomprehensive studies are needed.
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22
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2
