Solitary Metastasis Mimicking Glioblastoma in a Patient with Fahr's Disease

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dc.authoridOgul, Hayri/0000-0001-5989-3729;
dc.contributor.authorTaydas, Onur
dc.contributor.authorHas, Busra
dc.contributor.authorSakci, Zakir
dc.contributor.authorOgul, Hayri
dc.contributor.authorKantarci, Mecit
dc.date.accessioned2025-10-11T20:48:40Z
dc.date.available2025-10-11T20:48:40Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractFahr's disease is defined as the accumulation of bilateral idiopathic calcification in the basal ganglia, dentate nucleus, and centrum semiovale. The coexistence of Fahr's disease and intracranial tumors is extremely rare, with only five cases documented in the literature. This study aimed to present a rare case, discussing both similarities and differences with previously reported cases. A 70-year-old female patient presented to our hospital with a progressive headache over the past month. Brain magnetic resonance imaging (MRI) with intravenous contrast was performed for further evaluation. Bilateral basal ganglia, thalamus, and dentate nuclei showed calcifications consistent with Fahr's disease. After excluding toxic, infectious, and endocrine causes of calcification, the patient was diagnosed with Fahr's disease. Magnetic resonance imaging also revealed a midline localized, irregularly contoured, and heterogeneously intense mass with contrast enhancement at the centrum semiovale level, accompanied by peripheral edema. Radiologically, the mass resembled a high-grade glioma or metastasis, and the presence of a lipid peak further suggested metastasis. Based on radiological findings, the patient was diagnosed with brain metastasis of breast carcinoma. The patient received chemotherapy for metastasis, which resulted in substantial regression of the mass. In patients with known Fahr's disease, new-onset headaches and related symptoms should warrant evaluation for possible brain tumors. In these cases, imaging findings should be assessed along with physical examination findings and the patient's medical history to support the diagnostic process.en_US
dc.identifier.doi10.1007/s13193-024-02137-z
dc.identifier.endpage812en_US
dc.identifier.issn0975-7651
dc.identifier.issn0976-6952
dc.identifier.issue3en_US
dc.identifier.pmid40687874en_US
dc.identifier.scopus2-s2.0-85210573153en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage807en_US
dc.identifier.urihttps://doi.org/10.1007/s13193-024-02137-z
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22042
dc.identifier.volume16en_US
dc.identifier.wosWOS:001366650000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal of Surgical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectFahr's diseaseen_US
dc.subjectGlioblastomaen_US
dc.subjectMetastasisen_US
dc.subjectMagnetic resonance imagingen_US
dc.titleSolitary Metastasis Mimicking Glioblastoma in a Patient with Fahr's Diseaseen_US
dc.typeArticleen_US

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