Characteristics of Turkish children with Type 2 diabetes at onset: a multicentre, cross-sectional study

Basit Öğe Kaydı
dc.contributor.authorHatun, Şükrü
dc.contributor.authorMutlu, Gül Yeşiltepe
dc.contributor.authorCinaz, Peyami
dc.contributor.authorTuran, Serap
dc.contributor.authorEkberzade, Azad
dc.contributor.authorBereket, Abdullah
dc.contributor.authorŞıklar, Zeynep
dc.date.accessioned2020-04-30T22:40:42Z
dc.date.available2020-04-30T22:40:42Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionTuran, Serap/0000-0002-5172-5402; ABALI, SAYGIN/0000-0001-6552-2801; yesiltepe mutlu, gul/0000-0003-3919-7763; Demir, Korcan/0000-0002-8334-2422; Hatun, Sukru/0000-0003-1633-9570; UCAKTURK, Seyit Ahmet/0000-0001-8666-4454en_US
dc.descriptionWOS: 000487006600007en_US
dc.descriptionPubMed: 31099079en_US
dc.description.abstractAims To describe the baseline clinical and laboratory findings and treatment modalities of 367 children and adolescents diagnosed with Type 2 diabetes in various paediatric endocrinology centres in Turkey. Methods A standard questionnaire regarding clinical and laboratory characteristics at onset was uploaded to an online national database system. Data for 367 children (aged 6-18 years) newly diagnosed with Type 2 diabetes at 37 different paediatric endocrinology centres were analysed. Results After exclusion of the children with a BMI Z-score < 1 SD, those with genetic syndromes associated with Type 2 diabetes, and those whose C-peptide and/or insulin levels were not available, 227 cases were included in the study. Mean age was 13.8 +/- 2.2 (range 6.5-17.8) years, with female preponderance (68%). Family history of Type 2 diabetes was positive in 86% of the children. The mean BMI was 31.3 +/- 6.5 kg/m(2) (range 18.7-61) and BMI Z-score was 2.4 +/- 0.8 (range 1-5). More than half (57%) of the children were identified by an opportunistic diabetes screening due to existing risk markers without typical symptoms of diabetes. Only 13% (n = 29) were treated solely by lifestyle modification, while 40.5% (n = 92) were treated with metformin, 13% (n = 30) were treated with insulin, and 33.5% (n = 76) were treated with a combination of insulin and metformin initially. Mean HbA(1C) levels of the insulin and combination of insulin and metformin groups were 98 (11.1%) and 102 mmol/mol (11.5%), respectively, and also were significantly higher than the lifestyle modification only and metformin groups mean HbA(1C) levels (70(8.6%) and 67 mmol/mol (8.3%), respectively). Conclusions An opportunistic screening of children who are at high risk of Type 2 diabetes is essential, as our data showed that > 50% of the children were asymptomatic at diagnosis. The other important result of our study was the high rate of exclusion from the initial registration (38%), suggesting that accurate diagnosis of Type 2 diabetes in youth is still problematic, even for paediatric endocrinologists.en_US
dc.identifier.doi10.1111/dme.14038en_US
dc.identifier.endpage1250en_US
dc.identifier.issn0742-3071
dc.identifier.issn1464-5491
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1243en_US
dc.identifier.urihttps://doi.org/10.1111/dme.14038
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3040
dc.identifier.volume36en_US
dc.identifier.wosWOS:000487006600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDiabetic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleCharacteristics of Turkish children with Type 2 diabetes at onset: a multicentre, cross-sectional studyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
3040.pdf
Boyut:
823.62 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu