Evaluation of the systemic-immune inflammation index (SII) and systemic immune-inflammation response index (SIRI) in children with type 1 diabetes mellitus and its relationship with cumulative glycemic exposure

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dc.authoridArslanoglu, Ilknur/0000-0002-4975-9718en_US
dc.authoridOzde, Sukriye/0000-0002-0053-6222en_US
dc.authoridOZEL, Mehmet Ali/0000-0001-8817-5769en_US
dc.authoridCoskun, Gokhan/0000-0002-3587-9612en_US
dc.authoridOzde, Cem/0000-0001-8846-9185en_US
dc.authorscopusid56815156200en_US
dc.authorscopusid56805242800en_US
dc.authorscopusid56076143400en_US
dc.authorscopusid57208665904en_US
dc.authorscopusid6603074686en_US
dc.authorscopusid55513217600en_US
dc.authorscopusid36084223000en_US
dc.contributor.authorOzde, Sukriye
dc.contributor.authorAkture, Gulsah
dc.contributor.authorOzel, Mehmet Ali
dc.contributor.authorYavuzyilmaz, Fatma
dc.contributor.authorArslanoglu, Ilknur
dc.contributor.authorOzde, Cem
dc.contributor.authorKayapinar, Osman
dc.date.accessioned2024-08-23T16:04:01Z
dc.date.available2024-08-23T16:04:01Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjectives: In this study, the systemic proinflammatory status was assessed using the systemic immune-inflammation index (SII) and SIRI systemic immune-inflammatory response index (SIRI) in children and adolescents with type 1 diabetes mellitus (T1DM). Methods: The study involved 159 patients aged between 6 and 16 years. The SII and SIRI values were calculated based on the complete blood count. Basic blood biochemistry evaluated, and carotid intima-media thickness (cIMT) was measured and recorded. The cumulative glycemic exposure was calculated by multiplying the value above the normal reference range of the HbA1c value. The sum of all these values obtained from the time of diagnosis to obtain the cumulative glycemic exposure. All findings were compared statistically. All statistically significant parameters were evaluated in the multivariate logistic regression analysis. Results:The analysis revealed that only cIMT (Exp(B)/OR: 0.769, 95 % CI: 0.694-0.853, p<0.001), high-density lipoprotein (Exp(B)/OR: 3.924, 95 % CI: 2.335-6.596, p<0.001), monocyte count (Exp(B)/OR: 1.650, 95 % CI: 1.257-2.178, p<0.001), hematocrit (Exp(B)/OR: 0.675, 95 % CI: 0.523-0.870, p<0.001), and SIRI (Exp(B)/OR: 1.005, 95 % CI: 1.002-1.008, p<0.001) were significantly associated with T1DM. A statistically significant positive association was found between cumulative glycemic exposure and SIRI only (r=0.213, p=0.032). To our knowledge, this is the first study to evaluate SII and SIRI in children with type 1 diabetes. Conclusions: These findings indicate that SIRI could serve as a potential biomarker for detecting early-onset proatherosclerotic processes in diabetic children. However, further clinical studies are required to confirm this.en_US
dc.identifier.doi10.1515/jpem-2024-0043
dc.identifier.endpage643en_US
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue7en_US
dc.identifier.pmid38826052en_US
dc.identifier.scopus2-s2.0-85195258052en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage635en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2024-0043
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14013
dc.identifier.volume37en_US
dc.identifier.wosWOS:001237107000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttype 1 diabetesen_US
dc.subjectchildrenen_US
dc.subjectinflammationen_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectMedia Thicknessen_US
dc.subjectAtherosclerosisen_US
dc.subjectSearchen_US
dc.subjectYouthen_US
dc.subjectComplicationsen_US
dc.subjectChildhooden_US
dc.subjectMarkersen_US
dc.subjectOnseten_US
dc.titleEvaluation of the systemic-immune inflammation index (SII) and systemic immune-inflammation response index (SIRI) in children with type 1 diabetes mellitus and its relationship with cumulative glycemic exposureen_US
dc.typeArticleen_US

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