Relatively high levels of serum adiponectin in obese women, a potential indicator of anti-inflammatory dysfunction: Relation to sex hormone-binding globulin

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dc.contributor.authorOnat, Altan
dc.contributor.authorHergenç, Gülay
dc.contributor.authorDursunoğlu, Dursun
dc.contributor.authorKüçükdurmaz, Zekeriya
dc.contributor.authorBulur, Serkan
dc.contributor.authorCan, Günay
dc.date.accessioned2020-04-30T23:31:38Z
dc.date.available2020-04-30T23:31:38Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000260537100003en_US
dc.descriptionPubMed: 18695734en_US
dc.description.abstractIt is unclear whether serum adiponectin concentrations diminish linearly with increasing adiposity and, if not, which factors codetermine this association. These issues were investigated cross-sectionally in 1188 men and women, representative of middle-aged and elderly Turkish adults. Serum total adiponectin was assayed by ELISA. Serum adiponectin values in men, though declining significantly in transition from the bottom to the mid tertile of body mass index (BMI) and waist circumference (WC), were similar in the two respective upper tertiles. In women, serum adiponectin concentrations were not significantly different in any tertile of these indices, were significantly correlated with BMI or WC within the low tertiles and not within the two higher tertiles. In a linear regression analysis for WC (or BMI) in a subset of the sample in which serum sex hormone-binding globulin (SHBG) was available and which additionally comprised adiponectin, fasting insulin and other confounders, only insulin and, in women SHBG, were significantly associated, but not adiponectin. In linear regression analyses for covariates of adiponectin in two models comprising 12 variables, insulin and SHBG concentrations were significantly associated in both genders though not BMI. Whereas in men HDL-cholesterol and CRP were covariates of adiponectin (both p<0.01), SHBG and apolipoprotein B positively associated in women (p<0.001), independent of BMI and fasting insulin levels. Conclusions: Relationship between excess adiposity and adiponectin levels is inconsistent in Turkish adults. Independently from obesity and hyperinsulinemia, serum adiponectin discloses significant relationship with inflammatory markers and HDL only in men, not in women in whom it is influenced by SHBG, with consequent attenuation of its anti-inflammatory activities.en_US
dc.description.sponsorshipTurkish Society of Cardiology and SanofiAventis, IstanbulSanofi-Aventis; AstraZenecaAstraZeneca; NovartisNovartis; Pfizer, Istanbul, TurkeyPfizeren_US
dc.description.sponsorshipWe thank the Turkish Society of Cardiology and SanofiAventis, Istanbul, as well as the pharmaceutical companies AstraZeneca, Novartis and Pfizer, Istanbul, Turkey, that have supported financially the Turkish Adult Risk Factor survey 2005/06. We are indebted to I. Unsal, MD, S. Gogus and M. Menekse for the ELISA assays of serum adiponectin. We appreciate the dedicated works of S. Albayrak, MD, A. Karabulut, MD, A. M. Esen, MD, and Mr. M. Ozmay, the coworkers in the survey teams.en_US
dc.identifier.endpage214en_US
dc.identifier.issn1449-2288
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage208en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4371
dc.identifier.volume4en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIvyspring Int Publen_US
dc.relation.ispartofInternational Journal Of Biological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdiponectinen_US
dc.subjectanti-inflammatory functionen_US
dc.subjectgender differenceen_US
dc.subjectwaist circumferenceen_US
dc.subjectobesityen_US
dc.subjectsex hormone-binding globulinen_US
dc.titleRelatively high levels of serum adiponectin in obese women, a potential indicator of anti-inflammatory dysfunction: Relation to sex hormone-binding globulinen_US
dc.typeArticleen_US

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