The effect of apelin-13 on gastric ischemia/reperfusion injury: the roles of sensory nerves and vagus nerve

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dc.authoridBIRSEN, ILKNUR/0000-0002-8637-0250
dc.authorwosidBirsen, Ilknur/AAB-5648-2020
dc.contributor.authorBirsen, Ilknur
dc.contributor.authorIzgut-Uysal, V. Nimet
dc.contributor.authorSoylu, Hakan
dc.contributor.authorUstunel, Ismail
dc.date.accessioned2021-12-01T18:49:38Z
dc.date.available2021-12-01T18:49:38Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractApelin is a peptide that plays a role in physiological processes such as angiogenesis, apoptosis, and proliferation. The aim of this study was to investigate the role of capsaicin-sensitive afferent neurons and vagus in the effect of apelin against ischemia/reperfusion (I/R) injury. The experimental groups were (1) control, (2) I/R, (3) apelin + I/R, (4) vagotomy + I/R, (5) vagotomy + apelin + I/R, (6) capsaicin + I/R, (7) capsaicin + apelin + I/R, (8) lorglumide + I/R, and (9) lorglumide + apelin + I/R. To test the potential gastroprotective effect of apelin-13, apelin-13 (2 mg/kg i.v.) was administered just before both ischemia and reperfusion. A vagotomy was performed 1 week before I/R in the vagotomized groups; capsaicin (125 mg/kg s.c.) was administrated 2 weeks before I/R in the capsaicin-treated groups and lorglumide (5 mg/kg i.p.) was administered 30 min before I/R in the lorglumide-treated groups. After I/R, a variety parameters in gastric tissue were analyzed. cfos expression was determined in brainstem samples. In the I/R group, the lesion index, myeloperoxidase activity, lipid peroxidation, nitric oxide, and tumor necrosis factor-alpha increased, and mucosal blood flow, prostaglandin-E2, and calcitonin gene related peptide decreased. Apelin prevented the damaging effects of I/R and increased cfos expression in brainstem areas. Vagotomy, capsaicin, and lorglumide largely eliminated the gastroprotective effects of apelin-13. This study showed that sensory nerves and the vagus play regulatory roles in apelin-induced gastroprotection. Cholecystokinin may play a role in the effect of apelin through sensory neurons.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Akdeniz University in TurkeyAkdeniz University [TDK-2015-593]en_US
dc.description.sponsorshipThis work was supported by The Scientific Research Projects Coordination Unit of Akdeniz University in Turkey (Project No. TDK-2015-593).en_US
dc.identifier.doi10.1139/cjpp-2019-0502
dc.identifier.endpage295en_US
dc.identifier.issn0008-4212
dc.identifier.issn1205-7541
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85084326967en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage282en_US
dc.identifier.urihttps://doi.org/10.1139/cjpp-2019-0502
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10753
dc.identifier.volume98en_US
dc.identifier.wosWOS:000531856900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCanadian Science Publishingen_US
dc.relation.ispartofCanadian Journal Of Physiology And Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapelinen_US
dc.subjectvagusen_US
dc.subjectsensory nervesen_US
dc.subjectischemia/reperfusionen_US
dc.subjectdorsal motor nucleus of vagusen_US
dc.subjectBrain-Gut Axisen_US
dc.subjectWater-Immersionen_US
dc.subjectNitric-Oxideen_US
dc.subjectCholecystokininen_US
dc.subjectIschemiaen_US
dc.subjectGastroprotectionen_US
dc.subjectExpressionen_US
dc.subjectInflammationen_US
dc.subjectProtectionen_US
dc.subjectSecretionen_US
dc.titleThe effect of apelin-13 on gastric ischemia/reperfusion injury: the roles of sensory nerves and vagus nerveen_US
dc.typeArticleen_US

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