Association of Endothelial Nitric Oxide Synthase Gene Polymorphisms (894G/T,-786T/C, G10T) and Clinical Findings in Patients with Migraine

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dc.contributor.authorEröz, Recep
dc.contributor.authorBahadır, Anzel
dc.contributor.authorDikici, Süber
dc.contributor.authorTasdemir, Sener
dc.date.accessioned2020-04-30T22:39:53Z
dc.date.available2020-04-30T22:39:53Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000340096700006en_US
dc.descriptionPubMed: 24845269en_US
dc.description.abstractMigraine is a common neurological disorder characterized by recurrent attacks, unilateral head pain, and related symptoms. The aim of this study was to investigate three endothelial nitric oxide synthase (eNOS) polymorphisms in 176 patients with migraine and 123 healthy individuals. Clinical and biochemical parameters were investigated. Genetic analysis was performed using the polymerase chain reaction-restriction fragment length polymorphism method. The differences between migraine cases and the control group were significant for two polymorphisms (-786T/C and 894G/T) (p = 0.000). Homocysteine and body mass index (BMI) were significantly higher in the migraine group than in the control group (p = 0.001 and p = 0.000). The relation between -786T/C genotype and BMI and allodynia was significant. TC heterozygotes and CC homozygotes were significantly higher in the migraine group than in the control group (OR 2.843 and 95 % CI 1.681-4.808 and OR 3.729 and 95 % CI 1.784-7.792, respectively). The 894G/T genotype was correlated with BMI, pain intensity, age at the onset of migraine, nausea, tension, compression, and allodynia. For this polymorphism, GT heterozygotes and TT homozygotes were significantly higher in the migraine group than in the control group (OR 3.027 and 95 % CI 1.830-5.008 and OR 3.221 and 95 % CI 1.223-8.484, respectively). The G10T genotype was correlated with attack duration and age at the onset of migraine (p = 0.008 and p = 0.040). eNOS polymorphisms may be useful markers for assessing migraine risk and clinical diagnosis.en_US
dc.identifier.doi10.1007/s12017-014-8311-0en_US
dc.identifier.endpage593en_US
dc.identifier.issn1535-1084
dc.identifier.issn1559-1174
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage587en_US
dc.identifier.urihttps://doi.org/10.1007/s12017-014-8311-0
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2853
dc.identifier.volume16en_US
dc.identifier.wosWOS:000340096700006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofNeuromolecular Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecteNOS polymorphismen_US
dc.subjectMigraineen_US
dc.subjectClinical parametersen_US
dc.subjectAuraen_US
dc.subjectHomocysteineen_US
dc.titleAssociation of Endothelial Nitric Oxide Synthase Gene Polymorphisms (894G/T,-786T/C, G10T) and Clinical Findings in Patients with Migraineen_US
dc.typeArticleen_US

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