EFFECT OF L-CARNITINE IN PREVENTING SECONDARY DAMAGE IN TRAUMATIC BRAIN INJURY: AN EXPERIMENTAL STUDY

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dc.contributor.authorÇalıkoğlu, Çağatay
dc.contributor.authorAkgül, Osman
dc.contributor.authorAkgül, Mehmet Hüseyin
dc.contributor.authorGezen, Ahmet Ferruh
dc.contributor.authorAytekin, Hikmet
dc.contributor.authorDöşoğlu, Murat Servan
dc.contributor.authorErdem, Havva
dc.date.accessioned2020-05-01T09:11:42Z
dc.date.available2020-05-01T09:11:42Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000357346000002en_US
dc.description.abstractIntroduction: Prevention of secondary damage occurring after traumatic brain injury (TBI) reduces morbidity and mortality. The present study aimed to evaluate efficacy of L-carnitine, the benefit of which has been proven in many fields such as liver, kidney and neurological diseases, in the treatment of TBI. Matherials and method: Forty adult male Sprague-Dawley rats were included and divided into 4 groups, each containing 10 rats. The control group comprised subjects without induced head trauma and treatment. The trauma group comprised subjects with induced head trauma and no treatment. The carnitine group comprised subjects without induced head trauma and with L-carnitine treatment (100 mg/kg via intraperitoneal route for 6 times). The trauma+carnitine group comprised subjects with induced head trauma and L-carnitine treatment. Edema, inflammation, and neuronal damage were histopathologically examined. Results: In the trauma group, all subjects had edema, inflammation, and neuronal damage. In the control, carnitine, and trauma+carnitine groups, edema was detected in 5, 6, and 4 subjects, respectively; inflammation was detected in 2, 4, and 3 subjects, respectively; and neuronal damage was detected in 1, 3, and 7 subjects, respectively. Edema and neuronal damage scores were significantly higher in the trauma group than in the other groups. Inflammation rate was significantly higher in the trauma group than in the control and trauma+carnitine groups. Conclusion: Antiedema, anti-inflammatory, and neuroprotective effects of L-carnitine were histopathologically demonstrated in the rats with experimentally induced head trauma. L-carnitine could be a beneficial treatment option for edema and inflammation secondary to acute TBI in humans.en_US
dc.identifier.endpage784en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage777en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5729
dc.identifier.volume31en_US
dc.identifier.wosWOS:000357346000002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTraumatic brain injuryen_US
dc.subjectL-carnitineen_US
dc.subjectneuroprotectionen_US
dc.subjectbrain edemaen_US
dc.subjectinflammationen_US
dc.titleEFFECT OF L-CARNITINE IN PREVENTING SECONDARY DAMAGE IN TRAUMATIC BRAIN INJURY: AN EXPERIMENTAL STUDYen_US
dc.typeArticleen_US

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