Probiotic potential and wound-healing activity of Pediococcus pentosaceus strain AF2 isolated from Herniaria glabra L. which is traditionally used to make yogurt

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dc.authoridugras, serpil/0000-0002-1867-5781en_US
dc.authoridAGYAR YOLDAS, PINAR/0000-0002-9277-0648en_US
dc.authorscopusid54397548800en_US
dc.authorscopusid58661467300en_US
dc.authorscopusid58899822300en_US
dc.authorwosidugras, serpil/KSM-3256-2024en_US
dc.contributor.authorUgras, Serpil
dc.contributor.authorFidan, Aysenur
dc.contributor.authorYoldas, Pinar Agyar
dc.date.accessioned2024-08-23T16:07:16Z
dc.date.available2024-08-23T16:07:16Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractProbiotics have been a part of our lives for centuries, primarily through fermented foods. They find applications in various fields such as food, healthcare, and agriculture. Nowadays, their utilization is expanding, highlighting the importance of discovering new bacterial strains with probiotic properties suitable for diverse applications. In this study, our aim was to isolate new probiotic bacteria. Herniaria glabra L., a plant traditionally used for yogurt making in some regions and recognized in official medicine in many countries, was chosen as the source for obtaining probiotic bacteria. We conducted bacterial isolation from the plant, molecularly identified the isolated bacteria using 16S rRNA sequencing, characterized their probiotic properties, and assessed their wound-healing effects. As a result of these studies, we identified the bacterium isolated from the plant as Pediococcus pentosaceus strain AF2. We found that the strain AF2 exhibited high resistance to conditions within the gastrointestinal tract. Our reliability analysis showed that the isolate had gamma-hemolytic activity and displayed sensitivity to certain tested antibiotics. At the same time, AF2 did not show gelatinase and DNase activity. We observed that the strain AF2 produced metabolites with inhibitory activity against E. coli, B. subtilis, P. vulgaris, S. typhimurium, P. aeruginosa, K. pneumoniae, E. cloacae, and Y. pseudotuberculosis. The auto-aggregation value of the strain AF2 was calculated at 73.44%. Coaggregation values against E. coli and L. monocytogenes bacteria were determined to be 56.8% and 57.38%, respectively. Finally, we tested the wound-healing effect of the strain AF2 with cell culture studies and found that the strain AF2 promoted wound healing.en_US
dc.description.sponsorshipResearch Fund of Duzce University [DUE.BAP-2022.05.01.1290]en_US
dc.description.sponsorshipThis work was supported by the Research Fund of Duzce University (Project number; DUE.BAP-2022.05.01.1290).en_US
dc.identifier.doi10.1007/s00203-024-03831-w
dc.identifier.issn0302-8933
dc.identifier.issn1432-072X
dc.identifier.issue3en_US
dc.identifier.pmid38383810en_US
dc.identifier.scopus2-s2.0-85185652301en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s00203-024-03831-w
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14556
dc.identifier.volume206en_US
dc.identifier.wosWOS:001171123600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofArchives of Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHerniaria glabra L.en_US
dc.subjectPediococcus pentosaceusen_US
dc.subjectProbioticen_US
dc.subjectWound healingen_US
dc.subjectIn-Vitroen_US
dc.subjectLactobacillus Strainsen_US
dc.subjectSusceptibilityen_US
dc.subjectBacteriaen_US
dc.subjectAdhesionen_US
dc.subjectIntegrityen_US
dc.subjectStarteren_US
dc.subjectCellsen_US
dc.titleProbiotic potential and wound-healing activity of Pediococcus pentosaceus strain AF2 isolated from Herniaria glabra L. which is traditionally used to make yogurten_US
dc.typeArticleen_US

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