Comparison of the effects of N-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxication

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dc.contributor.authorKandiş, Hayati
dc.contributor.authorErkan, Melih Engin
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorGüneş, Harun
dc.contributor.authorErbaş, Mesut
dc.contributor.authorYıldırım, Hayriye A.K.
dc.contributor.authorKara, İsmail Hamdi
dc.date.accessioned2020-04-30T22:41:28Z
dc.date.available2020-04-30T22:41:28Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKARA, ISMAIL HAMDI/0000-0003-2022-1882; KARA, ISMAIL HAMDI/0000-0003-2022-1882; Kandis, Hayati/0000-0001-9151-6050en_US
dc.descriptionWOS: 000294473300023en_US
dc.descriptionPubMed: 21115557en_US
dc.description.abstractAim: The aim of the present study was to investigate the therapeutic and preventive effects of N-acetyl cysteine and erdosteine on renal injury associated with paracetamol (acetaminophen) intoxication. Materials and methods: Female albino Wistar rats were divided into six groups: control; paracetamol (1 g/kg, oral); paracetamol (1 g/kg, oral) + erdosteine (150 mg/kg/day, oral); paracetamol (1 g/kg, oral) + N-acetyl cysteine (140 mg/kg bolus, followed by 70 mg/kg, oral); N-acetyl cysteine control (140 mg/kg bolus, followed by 70 mg/kg, oral); and erdosteine control (150 mg/kg/day, oral). Potential renal injury was assessed using biochemical analyses, radionuclide imaging, and histopathological parameters. Results: In the paracetamol group, blood urea nitrogen and creatinine levels were significantly increased compared with controls. Histopathological examination showed tubular vacuolization, tubular necrosis, and remarkable interstitial inflammation. The excretion function was observed to be insufficient on radionuclide imaging. However, in the groups treated with erdosteine or N-acetyl cysteine after paracetamol, biochemical analyses, radionuclide imaging, and histopathological parameters showed significantly less evidence of renal toxicity than that observed in the group receiving paracetamol alone. Less renal toxicity was detected in rats receiving N-acetyl cysteine than in those receiving erdosteine. Conclusion: Renal injury may develop after paracetamol overdose. Erdosteine and N-acetyl cysteine are both effective in the prevention of renal injury when given in the early phase of paracetamol nephrotoxicity. N-acetyl cysteine is more protective than erdosteine.en_US
dc.identifier.doi10.1177/0960327110391384en_US
dc.identifier.endpage1358en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1350en_US
dc.identifier.urihttps://doi.org/10.1177/0960327110391384
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3191
dc.identifier.volume30en_US
dc.identifier.wosWOS:000294473300023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectparacetamolen_US
dc.subjecterdosteineen_US
dc.subjectN-acetyl cysteineen_US
dc.subjectrenal toxicityen_US
dc.subjectradionuclide imagingen_US
dc.titleComparison of the effects of N-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxicationen_US
dc.typeArticleen_US

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