Can argyrophilic nucleolar organizing region-associated protein amount be used for the detection of cardiac damage?

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dc.contributor.authorKandiş, Hayati
dc.contributor.authorAfacan, Mustafa Ahmet
dc.contributor.authorEröz, Recep
dc.contributor.authorÇolakoğlu, Serdar
dc.contributor.authorBayramoğlu, Ayşegül
dc.contributor.authorOktay, Murat
dc.date.accessioned2020-04-30T22:40:26Z
dc.date.available2020-04-30T22:40:26Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKARA, ISMAIL HAMDI/0000-0003-2022-1882; KARA, ISMAIL HAMDI/0000-0003-2022-1882; Bayramoglu, Atif/0000-0003-3053-1956; afacan, mustafa ahmet/0000-0003-1045-0681en_US
dc.descriptionWOS: 000369657300014en_US
dc.descriptionPubMed: 25813961en_US
dc.description.abstractIntroduction: Carbon monoxide (CO) is a colorless, tasteless, odorless, nonirritant gas and CO poisoning affects all organ systems. Aim: We aimed to detect any possible effects of CO exposure on the argyrophilic nucleolar organizing region (AgNOR)-associated protein synthesis of heart cells and whether there is any relationship between AgNOR protein amount and both carboxyhemoglobin (COHb) level and histopathological evaluation methods used for the detection of damage in heart tissue after CO exposure. Materials and Methods: The rats were divided into four groups (control, 1000, 3000, and 5000 ppm), each containing six rats. After CO intoxication, COHb levels were measured and the animals were killed on the 7th day. AgNOR staining was performed in the heart tissue. One hundred nuclei per rat were evaluated, and total AgNOR area/nuclear area and mean AgNOR number were analyzed for each nucleus. The CO exposure groups had significantly higher AgNOR values than the control group (p < 0.0001). According to cardiomyopathy (CMY) scoring methods, the differences between groups 3 and 4 and groups 1 and 2 were significant (p < 0.05). A significant positive correlation between AgNOR values and both CMY and COHb levels were detected. Conclusion: The detection of AgNOR protein amount may give information about the CMY levels and be used to detect the CO intoxication levels instead of COHb in later periods.en_US
dc.identifier.doi10.1177/0960327115579432en_US
dc.identifier.endpage331en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage323en_US
dc.identifier.urihttps://doi.org/10.1177/0960327115579432
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2984
dc.identifier.volume35en_US
dc.identifier.wosWOS:000369657300014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCO intoxicationen_US
dc.subjectAgNORen_US
dc.subjectcardiomyopathyen_US
dc.subjectCOHben_US
dc.titleCan argyrophilic nucleolar organizing region-associated protein amount be used for the detection of cardiac damage?en_US
dc.typeArticleen_US

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