The prognostic value of mean platelet volume in decompensated heart failure

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dc.contributor.authorKandiş, Hayati
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorOrdu, Serkan
dc.contributor.authorErden, İsmail
dc.contributor.authorÇağlar, Onur
dc.contributor.authorBaşar, Cengiz
dc.contributor.authorAydın, Mesut
dc.date.accessioned2020-04-30T23:34:09Z
dc.date.available2020-04-30T23:34:09Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKandis, Hayati/0000-0001-9151-6050en_US
dc.descriptionWOS: 000291979600011en_US
dc.descriptionPubMed: 20660896en_US
dc.description.abstractBackground Congestive heart failure (CHF) is a major public health problem that is related to substantial morbidity, impaired quality of life and diminished survival. Mean platelet volume (MPV) is an indicator of platelet activation. Aim To investigate whether there is a difference of MPV in patients with decompensated and stable heart failure (SHF), and test the prognostic value of MPV in decompensated heart failure (DHF). Methods 136 consecutive patients with DHF were enrolled. 71 with SHF were also enrolled for comparison. Patients were followed up for a mean of 18612 months. The primary endpoint was death from any cause. Clinical characteristics of patients with DHF who died during follow-up were compared with the those of the survivors. Results MPV was significantly higher in DHF group than in the SHF group. 71 patients died during the follow-up period (18612 months). Comparison with survivors revealed that mortality was associated with age, systolic blood pressure, pulmonary artery pressure, serum creatinine, urea and MPV. MPV was determined as an independent risk factor for mortality (OR 1.553, 95% CI 1.024 to 2.354, p = 0.038). Receiver operating characteristic analysis showed that MPV level on admission was a predictor of mortality (area under the curve (AUC) for in-hospital mortality was 0.716 (95% CI 0.632 to 0.789, p = 0.003) and AUC for 6-month mortality was 0.815 (95% CI 0.74 to 0.877, p < 0.001), respectively). Conclusion MPV is increased in patients with DHF. Also, MPV on admission is an independent predictor of in-hospital mortality and 6-month mortality.en_US
dc.identifier.doi10.1136/emj.2009.088401en_US
dc.identifier.endpage578en_US
dc.identifier.issn1472-0205
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage575en_US
dc.identifier.urihttps://doi.org/10.1136/emj.2009.088401
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5113
dc.identifier.volume28en_US
dc.identifier.wosWOS:000291979600011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherB M J Publishing Groupen_US
dc.relation.ispartofEmergency Medicine Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe prognostic value of mean platelet volume in decompensated heart failureen_US
dc.typeArticleen_US

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