Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort

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dc.authoridSokucu, Sinem/0000-0002-7184-2075
dc.authoridAnber, Tunahan/0000-0001-6938-9710
dc.authoridCilli, Aykut/0000-0001-9985-3502
dc.authoridAydin, Senay/0000-0003-4460-9056
dc.authoridAkgun, Metin/0000-0003-3404-4274
dc.authoridAltintas, Nejat/0000-0002-8603-2606
dc.authoridAksakal, Alperen/0000-0001-6883-3314
dc.contributor.authorPihtili, Aylin
dc.contributor.authorKiyan, Esen
dc.contributor.authorBalcan, Baran
dc.contributor.authorArbatli, Semih
dc.contributor.authorCilli, Aykut
dc.contributor.authorAltintas, Nejat
dc.contributor.authorUgurlu, Aylin Ozsancak
dc.date.accessioned2025-10-11T20:48:26Z
dc.date.available2025-10-11T20:48:26Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women. Objective We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry. Methods Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 centers were included in the current analysis. OSA was defined as an apnea-hypopnea index (AHI) >= 5 events/hour and was classified as mild, moderate, and severe according to AHI cut-offs 5, 15, and 30 events/hour, respectively. Results In all, 7130 patients (2259 women) were included. OSA was observed in 6323 (88.7 %), of whom 70.2 % were male and 29.8 % were female. In the OSA group, women were older (56.7 +/- 11.9 vs. 49.5 +/- 11.3 years; p < 0.001) and more obese (body mass index 34.3 +/- 7.2 vs. 31.4 +/- 5.6 kg/m(2); p < 0.001) and had lower AHI (29.8 +/- 24.1 vs. 36.8 +/- 26.2 events/h; p < 0.001) than men. Loud snoring and witnessed apnea were more common in men than in women whereas women were more frequently presented with insomnia, headache, and mood changes. Women had significantly less total sleep time, less sleep efficiency, and longer sleep latency compared with men (p < 0.001 for each). Additionally, comorbid diseases such as diabetes mellitus, hypertension, asthma, psychiatric disorders, hypothyroidism as well as drug use were more common in women than in men independent of age and obesity (p < 0.05 for each). Conclusions Our results suggest significant sex differences in clinical and polysomnographic features in this nationwide Turkish adult population. Women with OSA have more symptom burden and comorbidities despite having a less severe AHI.en_US
dc.description.sponsorshipTurkish Thoracic Societyen_US
dc.description.sponsorshipTurkish Thoracic Society.en_US
dc.identifier.doi10.1016/j.sleep.2024.12.018
dc.identifier.endpage234en_US
dc.identifier.issn1389-9457
dc.identifier.issn1878-5506
dc.identifier.pmid39721358en_US
dc.identifier.scopus2-s2.0-85212914713en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage228en_US
dc.identifier.urihttps://doi.org/10.1016/j.sleep.2024.12.018
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21928
dc.identifier.volume126en_US
dc.identifier.wosWOS:001394481500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSleep Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectSexen_US
dc.subjectObstructive sleep apneaen_US
dc.subjectPolysomnographyen_US
dc.subjectSymptomsen_US
dc.titleSex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohorten_US
dc.typeArticleen_US

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