Effects of combined estrogen and progesterone replacement treatment on detrusor contractility and histology in oophorectomized rats

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dc.contributor.authorSayharman, Sema Etiz
dc.contributor.authorTosun, Nihan
dc.contributor.authorAka, Nurettin
dc.contributor.authorKöse, Gültekin
dc.contributor.authorTekin, Ali
dc.contributor.authorGören, Zafer
dc.date.accessioned2020-05-01T09:11:54Z
dc.date.available2020-05-01T09:11:54Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000298013300019en_US
dc.descriptionPubMed: 21790883en_US
dc.description.abstractAim: The aim of this study was to investigate the effects of estrogen plus progesterone treatment administered after surgical menopause on morphological and muscarinic receptor sensitivity in detrusor muscle bands of rats. Materials and Methods: A total of 40 female Albino-Wistar rats were assigned into two groups to undergo surgical menopause with sham operation (n = 10) and bilateral oophorectomy (n = 30). Thirty oophorectomized rats were assigned into three groups for different treatments administered for 8 weeks beginning from the 7th postoperative day. At the end of the 8th postoperative week, laparotomy was performed in all of them and the urinary bladders were excised and investigated with light microscope. All statistical analysis and graphs were performed using GraphPad Prism version 4. P < 0.05 was considered to be statistically significant. Results: It was determined that average bodyweights were increased to some extent in oophorectomized and sham groups after treatment and while it was more marked in the group receiving estrogen therapy, bodyweights were decreased in the group receiving estrogen plus progesterone therapy. However, this was not statistically significant. No statistically significant difference was determined between the sham, placebo and 17-beta estradiol treatment groups regarding contractile response of urinary bladder tapes to carbachol (P > 0.05). Contractile responses of urinary bladder tapes of the estrogen plus progesterone treatment group were found to be statistically lower than the placebo group (P < 0.05). Conclusion: Our in vitro findings demonstrate that treatment with estrogen plus progesterone decreases muscarinic activity in oophorectomized rats, whereas estrogen-only treatment does not. Our study establishes the basis for further studies to answer whether combination of estrogen and progesterone treatment can restore detrusor overactivity associated with sex hormone defects seen at menopause.en_US
dc.identifier.doi10.1111/j.1447-0756.2011.01589.xen_US
dc.identifier.endpage1644en_US
dc.identifier.issn1341-8076
dc.identifier.issue11en_US
dc.identifier.startpage1638en_US
dc.identifier.urihttps://doi.org/10.1111/j.1447-0756.2011.01589.x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5806
dc.identifier.volume37en_US
dc.identifier.wosWOS:000298013300019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdetrusor contractilityen_US
dc.subjectestrogenen_US
dc.subjectmenopauseen_US
dc.subjectoophorectomized ratsen_US
dc.subjectprogesteroneen_US
dc.titleEffects of combined estrogen and progesterone replacement treatment on detrusor contractility and histology in oophorectomized ratsen_US
dc.typeArticleen_US

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