Can quantitative surface antigen levels and systemic immune-inflammation index be predictive as a new indicator for the initiation of treatment in chronic hepatitis b?

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dc.authoridköroğlu, mehmet/0000-0002-5620-792Xen_US
dc.authoridŞİRİN, Abdullatif/0000-0002-4001-9887en_US
dc.authoridAyvaz, Muhammed Ali/0000-0003-4575-2866en_US
dc.authorscopusid57899565200en_US
dc.authorscopusid57195302200en_US
dc.authorscopusid58916768200en_US
dc.authorscopusid57221847920en_US
dc.authorscopusid23484467000en_US
dc.authorwosidköroğlu, mehmet/GON-3329-2022en_US
dc.authorwosidŞİRİN, Abdullatif/HJI-9269-2023en_US
dc.authorwosidAyvaz, Muhammed Ali/HTR-8791-2023en_US
dc.contributor.authorKoroglu, Mehmet
dc.contributor.authorAyvaz, Muhammed Ali
dc.contributor.authorBakan, Suat Baran
dc.contributor.authorSirin, Abdullatif
dc.contributor.authorAkyuz, Umit
dc.date.accessioned2024-08-23T16:04:18Z
dc.date.available2024-08-23T16:04:18Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjectives The natural history of chronic HBV infection (CHB) is generally divided into four phases: HBeAg-positive chronic HBV infection (EPCI) and -hepatitis (EPCH), HBeAg-negative chronic HBV infection (ENCI) and -hepatitis (ENCH). This study aimed to investigate changes in serum quantitative surface antigen (qHBsAg), systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) in a large number of CHB patients. Method Three hundred seventy-two CHB patients who underwent liver biopsy between January 2015 and February 2020 were evaluated. Results The SII-values were strongly significant between EPCI-EPCH (P = 0.002), however, there was significant difference between ENCI-ENCH (P = 0.025). Considering the SIRI results, there was a significant difference between both EPCI-EPCH (P = 0.009) and ENCI-ENCH (P = 0.118). In HBeAg-positive patients HBV-DNA, qHBsAg, and SII were found to be predictive (P = 0.029, P = 0.039, P = 0.027, respectively) while in HBeAg-negative patients, age, AST, HBV-DNA, qHBsAg, SII, and SIRI were found to be predictive (P = 0.047, P = 0.084, P = <0.001, P = 0.001, P = 0.012, P = 0.002, respectively). In EPCH phase, whereby accuracy rate results of HBV-DNA, qHBsAg, and SII were 75.3%, 73.4%, and 60.4%, respectively, while in the ENCH phase the accuracy rates of age, AST, HBV-DNA, qHBsAg, SII, and SIRI values were 57.8%, 65.6%, 68.3%, 63.8%, 57.3% and 53.2%, respectively. Conclusion HBV-DNA, qHBsAg, and SII are predictive in EPCH patients. Age, AST, HBV-DNA, qHBsAg, SII and SIRI are all predictive in ENCH patients. In patients with CHB, we recommend using SII to distinguish between EPCI-EPCH and ENCI-ENCH. Based on its sensitivity and features, we believe that qHBsAg and SII are suitable measuring instruments in discrimination both of EPCI-EPCH and ENCI-ENCH.en_US
dc.identifier.doi10.1097/MEG.0000000000002737
dc.identifier.endpage497en_US
dc.identifier.issn0954-691X
dc.identifier.issn1473-5687
dc.identifier.issue4en_US
dc.identifier.pmid38407853en_US
dc.identifier.scopus2-s2.0-85186515742en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage489en_US
dc.identifier.urihttps://doi.org/10.1097/MEG.0000000000002737
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14159
dc.identifier.volume36en_US
dc.identifier.wosWOS:001183671900003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal of Gastroenterology & Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAPRIen_US
dc.subjectchronic hepatitis Ben_US
dc.subjectFIB-4en_US
dc.subjectsurface antigenen_US
dc.subjectsystemic immune-inflammation indexen_US
dc.subjectsystemic inflammatory response indexen_US
dc.subjectPlatelet Ratio Indexen_US
dc.subjectTo-Lymphocyte Ratioen_US
dc.subjectSerum Hbv Dnaen_US
dc.subjectLiver Fibrosisen_US
dc.subjectAspartate-Aminotransferaseen_US
dc.subjectHepatocellular-Carcinomaen_US
dc.subjectAlanine Aminotransferaseen_US
dc.subjectMechanical Thrombectomyen_US
dc.subjectHbsag Quantificationen_US
dc.subjectBlood Neutrophilen_US
dc.titleCan quantitative surface antigen levels and systemic immune-inflammation index be predictive as a new indicator for the initiation of treatment in chronic hepatitis b?en_US
dc.typeArticleen_US

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