Effect of Oral plus Topical and Only Topical Tranaxamic Acid Application on Blood Loss and Postoperative Transfusion in Primary Total Hip Arthroplasty

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dc.authoridArican, Mehmet/0000-0002-0649-2339
dc.authoridSaglam, Sonmez/0000-0003-2651-8003
dc.authoridturhan, yalcin/0000-0002-1440-9566
dc.authoridKaraduman, Zekeriya Okan/0000-0002-6719-3666
dc.authoridDalaslan, Rasit Emin/0000-0001-5068-8024;
dc.contributor.authorMutlu, Tansel
dc.contributor.authorArican, Mehmet
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorTurhan, Yalcin
dc.contributor.authorKaban, Ilyas
dc.contributor.authorDalaslan, Rasit Emin
dc.contributor.authorSaglam, Sonmez
dc.date.accessioned2025-10-11T20:47:47Z
dc.date.available2025-10-11T20:47:47Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjectives: Total hip arthroplasty is one of the most common procedures performed to reduce pain and improve hip functions in patients with advanced hip osteoarthritis, but perioperative blood loss, acute anemia and transfusion requirement increase the risk of morbidity and mortality during and after surgery and negatively affect functional recovery. We aimed to present the comparative results of oral + topical and only topical tranexamic acid application to reduce blood loss and postoperative transfusion in primary total hip arthroplasty. Methods: We retrospectively evaluated the patients who applied to the Orthopedics and Traumatology outpatient clinic with complaints of hip pain and limited movement between January 2014 and December 2020, who underwent primary total hip arthroplasty with the diagnosis of coxarthrosis and who were administered oral + topical and only topical tranexamic acid before and during surgery, in terms of blood loss and transfusion requirement. Results: No statistically significant difference was observed between the preoperative, day 0 and day 1 hemoglobin means in those that were applied oral + topical tranexamic acid and those that were applied only topical (p > 0.05). However, the second- and third-day hemoglobin means in those that were treated with topical medication alone were found to be statistically significantly lower than in those that were treated with oral + topical tranexamic acid (p = 0.032, p = 0.0001). Conclusions: Oral + topical tranexamic acid application in total hip arthroplasty surgery is more effective than topical applications alone when it comes to reducing blood loss, hemoglobin and hematocrit decrease without increasing the risk of thromboembolic diseases and wound complications.en_US
dc.identifier.doi10.3390/jcm14041275
dc.identifier.issn2077-0383
dc.identifier.issue4en_US
dc.identifier.pmid40004805en_US
dc.identifier.scopus2-s2.0-85218894691en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/jcm14041275
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21558
dc.identifier.volume14en_US
dc.identifier.wosWOS:001432498800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofJournal of Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjecttranexamic aciden_US
dc.subjectarthroplastyen_US
dc.subjectreplacementen_US
dc.subjecthipen_US
dc.titleEffect of Oral plus Topical and Only Topical Tranaxamic Acid Application on Blood Loss and Postoperative Transfusion in Primary Total Hip Arthroplastyen_US
dc.typeArticleen_US

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