Investigation of the Effects of Acute and Chronic PTZ Model Epilepsy in Rats Exposed to Neonatal Hyperoxia on Bdnf, Ngf, Cyt c, Bax, and Bcl-2 Gene Expression Levels in the Brain

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dc.authoridKILIÇ, Ümit/0000-0001-9917-0648en_US
dc.authoridOnal, Cansu/0000-0003-2701-3250en_US
dc.authoridSoyturk, Hayriye/0000-0002-0000-3768en_US
dc.authorscopusid57204184451en_US
dc.authorscopusid57194432176en_US
dc.authorscopusid57219390008en_US
dc.authorwosidKILIÇ, Ümit/KEJ-4241-2024en_US
dc.contributor.authorOnal, Cansu
dc.contributor.authorKilic, Umit
dc.contributor.authorSoyturk, Hayriye
dc.date.accessioned2024-08-23T16:03:27Z
dc.date.available2024-08-23T16:03:27Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the relationship between acute and chronic epilepsy that may occur in adulthood, gene expression levels, and the possible mechanism of neuronal loss in rats exposed to hyperoxia in the postnatal period. Methods: The study was started with 12 female rats (mother rat). Two main groups were formed: six control and six hyperoxia groups. At the end of the experiment, brain tissue samples were collected and Bdnf, Ngf, Cyt c, Bax, and Bcl-2 gene expressions were studied by quantitative polymerase chain reaction. Bax (Bcl-2 associated X-protein) and Cytochrome (Cyt) c gene expression levels were found to be significantly higher in the hyperoxia-epilepsy groups, especially in the male group, than in the other groups (p<0.05). Results: While the Ngf gene expression level increases significantly in females due to epilepsy, it is independent of hyperoxy (p<0.05). Bdnf gene expression levels were found to be affected by hyperoxia in both males and females (p<0.05). In our study, a significant increase in Bax and Cyt c gene expression levels was observed in the neonatal hyperoxia and epilepsy group. Conclusion: It is thought that this increase in gene expression levels molecularly supports neuronal loss, but the related pathways will be better clarified with further studies.en_US
dc.identifier.doi10.4274/ArchEpilepsy.2023.23086
dc.identifier.endpage104en_US
dc.identifier.issn2792-0550
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85197401074en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage96en_US
dc.identifier.trdizinid1252693en_US
dc.identifier.urihttps://doi.org/10.4274/ArchEpilepsy.2023.23086
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1252693
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13763
dc.identifier.volume29en_US
dc.identifier.wosWOS:001176404100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofArchives of Epilepsyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyperoxiaen_US
dc.subjectneonatal hyperoxiaen_US
dc.subjectepilepsyen_US
dc.subjectgene expressionen_US
dc.subjectCell-Deathen_US
dc.subjectFamilyen_US
dc.subjectInjuryen_US
dc.subjectHippocampusen_US
dc.subjectApoptosisen_US
dc.subjectProteinsen_US
dc.subjectProtectsen_US
dc.subjectDeficitsen_US
dc.subjectOxygenen_US
dc.subjectDamageen_US
dc.titleInvestigation of the Effects of Acute and Chronic PTZ Model Epilepsy in Rats Exposed to Neonatal Hyperoxia on Bdnf, Ngf, Cyt c, Bax, and Bcl-2 Gene Expression Levels in the Brainen_US
dc.typeArticleen_US

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