The Role of Melatonin, IL-8 and IL-10 in Intrahepatic Cholestasis of Pregnancy

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dc.authoridGUVEY, HURI/0000-0002-8603-6981
dc.authorwosidGuvey, Huri/AAG-5645-2021
dc.contributor.authorCelik, Samettin
dc.contributor.authorGuve, Huri
dc.contributor.authorCaliskan, Canan
dc.contributor.authorCelik, Sebahattin
dc.date.accessioned2021-12-01T18:49:50Z
dc.date.available2021-12-01T18:49:50Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractIntroduction Intrahepatic cholestasis of pregnancy is a pregnancy-specific liver disease that usually emerges during the third trimester of pregnancy. It is characterized by itching and elevated serum total bile acid levels, and it may lead to severe fetal complications. This study aimed to investigate the role of interleukin-8, a pro-inflammatory cytokine; interleukin-10, an anti-inflammatory cytokine; and melatonin in intrahepatic cholestasis of pregnancy. Materials and Methods This prospective, case-controlled study was conducted with 51 women with intrahepatic cholestasis of pregnancy (40 mild and 11 severe cases) and 43 healthy pregnant women. Serum interleukin- 8, interleukin-10, and melatonin levels were evaluated. Results Melatonin and interleukin -10 were significantly lower in subjects with intrahepatic cholestasis of pregnancy (p = 0.001; p = 0.001, respectively p < 0.05). Interleukin-8 levels were found to be significantly higher in the cholestasis group than control group (p = 0.001, p < 0.05). Conclusions Because interleukin-8, interleukin-10, and melatonin were found to be significantly correlated with intrahepatic cholestasis of pregnancy, we believe this finding could shed light on the etiology of the disease.en_US
dc.identifier.doi10.1055/a-1233-9084
dc.identifier.endpage243en_US
dc.identifier.issn0948-2393
dc.identifier.issn1439-1651
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85091930530en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage238en_US
dc.identifier.urihttps://doi.org/10.1055/a-1233-9084
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10786
dc.identifier.volume225en_US
dc.identifier.wosWOS:000570153900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofZeitschrift Fur Geburtshilfe Und Neonatologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntrahepatic cholestasis of pregnancyen_US
dc.subjectmelatoninen_US
dc.subjectinterleukin-8en_US
dc.subjectinterleukin-10en_US
dc.subjectInflammationen_US
dc.titleThe Role of Melatonin, IL-8 and IL-10 in Intrahepatic Cholestasis of Pregnancyen_US
dc.typeArticleen_US

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