Association of diabetic ketoacidosis and HbA1c at onset with year-three HbA1c in children and adolescents with type 1 diabetes: Data from the International SWEET Registry

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dc.authoridKim, Jae Hyun/0000-0002-0203-7443
dc.authoridSchwandt, Anke/0000-0003-3041-0759
dc.authoridJefferies, Craig/0000-0002-0541-6094
dc.authoridPiccini, Barbara/0000-0002-2684-8638
dc.authorwosidJefferies, craig/ABA-1921-2021
dc.authorwosidKim, Jae Hyun/S-1459-2019
dc.contributor.authorPiccini, Barbara
dc.contributor.authorSchwandt, Anke
dc.contributor.authorJefferies, Craig
dc.contributor.authorKordonouri, Olga
dc.contributor.authorLimbert, Catarina
dc.contributor.authorArslanoglu, Ilknur
dc.contributor.authorRami-Merhar, Birgit
dc.date.accessioned2021-12-01T18:51:15Z
dc.date.available2021-12-01T18:51:15Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractObjective To establish whether diabetic ketoacidosis (DKA) or HbA1c at onset is associated with year-three HbA1c in children with type 1 diabetes (T1D). Methods Children with T1D from the SWEET registry, diagnosed <18 years, with documented clinical presentation, HbA1c at onset and follow-up were included. Participants were categorized according to T1D onset: (a) DKA (DKA with coma, DKA without coma, no DKA); (b) HbA1c at onset (low [<10%], medium [10 to <12%], high [>= 12%]). To adjust for demographics, linear regression was applied with interaction terms for DKA and HbA1c at onset groups (adjusted means with 95% CI). Association between year-three HbA1c and both HbA1c and presentation at onset was analyzed (Vuong test). Results Among 1420 children (54% males; median age at onset 9.1 years [Q1;Q3: 5.8;12.2]), 6% of children experienced DKA with coma, 37% DKA without coma, and 57% no DKA. Year-three HbA1c was lower in the low compared to high HbA1c at onset group, both in the DKA without coma (7.1% [6.8;7.4] vs 7.6% [7.5;7.8], P = .03) and in the no DKA group (7.4% [7.2;7.5] vs 7.8% [7.6;7.9], P = .01), without differences between low and medium HbA1c at onset groups. Year-three HbA1c did not differ among HbA1c at onset groups in the DKA with coma group. HbA1c at onset as an explanatory variable was more closely associated with year-three HbA1c compared to presentation at onset groups (P = .02). Conclusions Year-three HbA1c is more closely related to HbA1c than to DKA at onset; earlier hyperglycemia detection might be crucial to improving year-three HbA1c.en_US
dc.description.sponsorshipInsulet; Sanofi; Medtronic EuropeMedtronic; Lilly Diabetes Excellence Centre; DexCom Inc.; AbbottAbbott Laboratories; Boehringer-IngelheimBoehringer Ingelheimen_US
dc.description.sponsorshipInsulet; Sanofi; Medtronic Europe; Lilly Diabetes Excellence Centre; DexCom Inc.; Boehringer-Ingelheim; Abbotten_US
dc.identifier.doi10.1111/pedi.12946
dc.identifier.issn1399-543X
dc.identifier.issn1399-5448
dc.identifier.issue2en_US
dc.identifier.pmid31797499en_US
dc.identifier.scopus2-s2.0-85076755788en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/pedi.12946
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10985
dc.identifier.volume21en_US
dc.identifier.wosWOS:000503343500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectchildrenen_US
dc.subjectdiabetic ketoacidosisen_US
dc.subjectmetabolic controlen_US
dc.subjecttype 1 diabetesen_US
dc.subjectMetabolic-Controlen_US
dc.subjectDiagnosisen_US
dc.subjectFrequencyen_US
dc.subjectPredictoren_US
dc.subjectTrackingen_US
dc.subjectHba(1C)en_US
dc.subjectYouthen_US
dc.titleAssociation of diabetic ketoacidosis and HbA1c at onset with year-three HbA1c in children and adolescents with type 1 diabetes: Data from the International SWEET Registryen_US
dc.typeArticleen_US

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