Protective role of heparin in the injury of the liver and kidney on the experimental model of ischemia/reperfusion

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dc.contributor.authorYener, Ali Ümit
dc.contributor.authorÇiçek, Mustafa Cüneyt
dc.contributor.authorGenç, Serhat Bahadır
dc.contributor.authorÖzkan, Turgut
dc.contributor.authorDoğan, Emre
dc.contributor.authorBilgin, Bülent Çağlar
dc.contributor.authorAnkaralı, Handan
dc.date.accessioned2020-04-30T13:33:11Z
dc.date.available2020-04-30T13:33:11Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionPubMed ID: 24533613en_US
dc.description.abstractBackground: Surgery of thoracoabdominal aortic aneurysms (TAAA) is associated with high incidence of serious complications. Ischemia/reperfusion (I/R) injury may be responsible for these complications. We investigated the effect of degree of anticoagulation on remote organ I/R injuries and whether heparin is protective against I/R injury in addition to its anticoagulant properties.Methods: Spraque Dawley rats were used to determine both liver and kidney concentrations of HSP-70,IL-6, MPO in four groups: ischemic control (operation with cross-clamping and intraperitoneal administration of 0.9% saline, n = 7), sham (operation without cross-clamping, n = 7), heparin (ACT level about 200), and high dose heparin (ACT level up to 600). Histological analyses of the organs were performed.Results: Histopathological evaluation of kidney presented significant differences between groups with regards to the cytoplasmic vacuole formation, hemorrhage, tubular cell degeneration and tubular dilatation while heparinized group had best results. The kidney MPO and HSP-70 levels significantly decreased (p < 0.05), but IL-6 level was not significant (p > 0.05) in heparinized group when compared to ischemic control group. No statistically significant intergroup differences were detected in the tissue samples of liver. Immunohistochemical markers of the liver were compared and no statistically significant difference was found among the groups.Conclusion: Heparin is an important anticoagulation agent in TAAA surgical procedures but the use of higher levels of heparin in the present study revealed no beneficial effects. Bleeding complications is much less when heparin is used in the real-world clinical practice as ACT levels of 200. © 2014 Yener et al.; licensee BioMed Central Ltd.en_US
dc.identifier.doi10.1186/1749-8090-9-35en_US
dc.identifier.issn1749-8090
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1186/1749-8090-9-35
dc.identifier.urihttps://hdl.handle.net/20.500.12684/567
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Cardiothoracic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHeparin; Ischemia; Kidney; Lung; Reperfusionen_US
dc.titleProtective role of heparin in the injury of the liver and kidney on the experimental model of ischemia/reperfusionen_US
dc.typeArticleen_US

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